Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA)
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 7w1y
Q-score: 0.595
Li J, Dong J, Wang W, Yu D, Fan X, Hui YC, Lee CSK, Lam WH, Alary N, Yang Y, Zhang Y, Zhao Q, Chen CL, Tye BK, Dang S, Zhai Y
Cell (2023) 186 pp. 98-111.e21 [ DOI: doi:10.1016/j.cell.2022.12.008 Pubmed: 36608662 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna (Complex)
- Zinc ion (65 Da, Ligand)
- Isoform 2 of dna replication licensing factor mcm3 (96 kDa, Protein from Homo sapiens)
- Dna (49-mer) (15 kDa, DNA from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Human mini-chromosome maintenance complex (1 MDa, Complex from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna (49-mer) (14 kDa, DNA from Homo sapiens)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm 2/3/4/5/6/7 (Complex from Homo sapiens)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7v3u
Q-score: 0.514
Cheng J, Li N, Huo Y, Dang S, Tye BK, Gao N, Zhai Y
Nat Commun (2022) 13 pp. 1396-1396 [ Pubmed: 35296675 DOI: doi:10.1038/s41467-022-29070-5 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae S288C)
- Mcm double hexamer (dh) (Complex from Saccharomyces cerevisiae S288c)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae S288C)
- Magnesium ion (24 Da, Ligand)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae S288C)
Cryo-EM structure of MCM double hexamer bound with DDK in State I
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7v3v
Q-score: 0.477
Cheng J, Li N, Huo Y, Dang S, Tye BK, Gao N, Zhai Y
Nat Commun (2022) 13 pp. 1396-1396 [ Pubmed: 35296675 DOI: doi:10.1038/s41467-022-29070-5 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae S288C)
- Cell division control protein 7 (58 kDa, Protein from Saccharomyces cerevisiae S288C)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae S288C)
- Magnesium ion (24 Da, Ligand)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dh-ddk (state i) (Complex from Saccharomyces cerevisiae S288c)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae S288C)
- Ddk kinase regulatory subunit dbf4 (80 kDa, Protein from Saccharomyces cerevisiae S288C)
Cryo-EM structure of MCM double hexamer
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 7w8g
Q-score: 0.574
Cheng J, Li N, Huo Y, Dang S, Tye BK, Gao N, Zhai Y
Nat Commun (2022) 13 pp. 1396-1396 [ Pubmed: 35296675 DOI: doi:10.1038/s41467-022-29070-5 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae S288C)
- Mcm double hexamer (dh) (Complex from Saccharomyces cerevisiae S288c)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae S288C)
- Magnesium ion (24 Da, Ligand)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae S288C)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 5zr1
Q-score: 0.547
Li N, Lam WH, Zhai Y, Cheng J, Cheng E, Zhao Y, Gao N, Tye BK
Nature (2018) 559 pp. 217-222 [ Pubmed: 29973722 DOI: doi:10.1038/s41586-018-0293-x ]
- Origin recognition complex subunit 5 (55 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- 72bp-oring dna, acs305, t-rich (22 kDa, DNA from Saccharomyces cerevisiae)
- Origin recognition complex subunit 6 (50 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Origin recognition complex subunit 2 (71 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Origin recognition complex subunit 4 (60 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Saccharomyces cerevisiae origin recognition complex bound to a 72-bp origin dna containing acs and b1 element (Complex from Saccharomyces cerevisiae)
- 72bp-oring dna, acs305, a-rich (22 kDa, DNA from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Origin recognition complex subunit 3 (72 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Origin recognition complex subunit 1 (104 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Cryo-EM structure of the Cdt1-MCM2-7 complex in AMPPNP state
Resolution: 7.1 Å
EM Method: Single-particle
Fitted PDBs: 5xf8
Q-score: 0.257
Zhai Y, Cheng E, Wu H, Li N, Yung PY, Gao N, Tye BK
Nat Struct Mol Biol (2017) 24 pp. 300-308 [ Pubmed: 28191894 DOI: doi:10.1038/nsmb.3374 ]
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Cdt1-mcm2-7 (Complex from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Cell division cycle protein cdt1 (68 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))