Structure of the plasma coagulation Factor XIII A2B2 heterotetrameric complex.
Singh S, Hagelueken G, Ugurlar D, Ramaraje Urs SU, Sharma A, Mahapatra M, Drepper F, Imhof D, Huesgen PF, Oldenburg J, Geyer M, Biswas A
Blood (2025) 145 pp. 438-449 [ DOI: doi:10.1182/blood.2024025369 Pubmed: 39447073 ]
- Factor xiii a2b2 heterotetramer (Complex from Homo sapiens)
- Coagulation factor xiii a chain (83 kDa, Protein from Homo sapiens)
- Coagulation factor xiii b chain (75 kDa, Protein from Homo sapiens)
High resolution structure of the coagulation Factor XIII A2B2 heterotetramer complex.
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 8cmu
Q-score: 0.601
Singh S, Hagelueken G, Ugurlar D, Ramaraje Urs SU, Sharma A, Mahapatra M, Drepper F, Imhof D, Huesgen PF, Oldenburg J, Geyer M, Biswas A
Blood (2025) 145 pp. 438-449 [ DOI: doi:10.1182/blood.2024025369 Pubmed: 39447073 ]
- Factor xiii a2b2 heterotetramer (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Coagulation factor xiii a chain (83 kDa, Protein from Homo sapiens)
- Coagulation factor xiii b chain (75 kDa, Protein from Homo sapiens)
Ugurlar D, Howes SC, de Kreuk BJ, Koning RI, de Jong RN, Beurskens FJ, Schuurman J, Koster AJ, Sharp TH, Parren PWHI, Gros P
Science (2018) 359 pp. 794-797 [ DOI: doi:10.1126/science.aao4988 Pubmed: 29449492 ]
- C1 complex (Complex from Homo sapiens)
- Igg1 antibodies (Complex from Homo sapiens)
- C1-igg1 complex on liposomes (700 kDa, Complex from Homo sapiens)
Cryo-EM reconstruction of C1-IgG1 complex
Resolution: 10.0 Å
EM Method: Single-particle
Fitted PDBs: 6fcz
Q-score: 0.013
Ugurlar D, Howes SC, de Kreuk BJ, Koning RI, de Jong RN, Beurskens FJ, Schuurman J, Koster AJ, Sharp TH, Parren PWHI, Gros P
Science (2018) 359 pp. 794-797 [ DOI: doi:10.1126/science.aao4988 Pubmed: 29449492 ]
- C1-igg1 complex (Complex)
- Complement c1q subcomponent subunit a (14 kDa, Protein from Homo sapiens)
- Complement c1q subcomponent subunit b (14 kDa, Protein from Homo sapiens)
- Immunoglobulin gamma-1 heavy chain (24 kDa, Protein from Homo sapiens)
- Immunoglobulin gamma-1 (Complex from Homo sapiens)
- Complement c1q (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Complement c1q subcomponent subunit c (14 kDa, Protein from Homo sapiens)
Cryo-electron tomography average of an C1-IgG complex
Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJR, van de Winkel JGJ, Wilson IA, Koster AJ, Taylor RP, Ollmann Saphire E, Burton DR, Schuurman J, Gros P, Parren PWHI
Science (2014) 343 pp. 1260-1263 [ Pubmed: 24626930 DOI: doi:10.1126/science.1248943 ]
- Dnp-haptenated liposomes, polyclonal goat anti-dnp antibody, human c1 (originating from c4 depleted serum) (1 MDa, Sample)
- C1 (766 kDa, Protein from Homo sapiens)
- Polyclonal igg (150 kDa, Protein from Capra hircus)
Cryo-electron tomography average of an C1-IgG complex
Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJR, van de Winkel JGJ, Wilson IA, Koster AJ, Taylor RP, Ollmann-Saphire E, Burton DR, Schuurman J, Gros P, Parren PWHI
Science (2014) 343 pp. 1260-1263 [ Pubmed: 24626930 DOI: doi:10.1126/science.1248943 ]
- Dnp-haptenated liposomes, polyconal goat anti-dnp antibody, human c1 (originating from c4 depleted serum) (1 MDa, Sample)
- C1 (766 kDa, Protein from Homo sapiens)
- Polyclonal igg (150 kDa, Protein from Capra hircus)
electron tomography average of an IgG hexamer
Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJR, van de Winkel JGJ, Wilson IA, Koster AJ, Taylor RP, Ollmann-Saphire E, Burton DR, Schuurman J, Gros P, Parren PWHI
Science (2014) 343 pp. 1260-1263 [ Pubmed: 24626930 DOI: doi:10.1126/science.1248943 ]
- Igg1-005-rgy monoclonal antibody (890 kDa, Sample)
- Igg1-005-e345r-e430g-s440y (148 kDa, Protein from Homo sapiens)