Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7qvm
Q-score: 0.423
Waltenspuhl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Pluckthun A
Nat Commun (2022) 13 pp. 4153-4153 [ DOI: doi:10.1038/s41467-022-31325-0 Pubmed: 35851571 ]
- Otr in complex with oxytocin, heterotrimeric mini-gq chimera (goqi) and scfv16 (Complex)
- Heterotrimeric mini-gq chimera (goqi) and oxytocin receptor (Complex from Homo sapiens)
- Oxytocin (1 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Antibody fragment scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Oxytocin receptor (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha,cdna flj31446 fis, clone nt2ne2000909, highly similar to guanine nucleotide-binding protein g(o) subunit alpha 1 (25 kDa, Protein from Homo sapiens)
- Oxytocin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 7p00
Q-score: 0.546
Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A
Sci Adv (2021) 7 pp. eabk2872-eabk2872 [ Pubmed: 34878828 DOI: doi:10.1126/sciadv.abk2872 ]
- Substance p (1 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (32 kDa, Protein from Mus musculus)
- Substance-p receptor (44 kDa, Protein from Homo sapiens)
- Nk1r in complex with substance p, heterotrimeric mini-gq chimera (gsqi) and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Human Neurokinin 1 receptor (NK1R) substance P Gs complex
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7p02
Q-score: 0.502
Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A
Sci Adv (2021) 7 pp. eabk2872-eabk2872 [ Pubmed: 34878828 DOI: doi:10.1126/sciadv.abk2872 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Substance-p receptor (44 kDa, Protein from Homo sapiens)
- Nk1r in complex with substance p, heterotrimeric mini-gs chimera (gsi) and scfv16 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Protachykinin-1 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (32 kDa, Protein from Mus musculus)