Lempp FA, Soriaga LB, Montiel-Ruiz M, Benigni F, Noack J, Park YJ, Bianchi S, Walls AC, Bowen JE, Zhou J, Kaiser H, Joshi A, Agostini M, Meury M, Dellota Jr E, Jaconi S, Cameroni E, Martinez-Picado J, Vergara-Alert J, Izquierdo-Useros N, Virgin HW, Lanzavecchia A, Veesler D, Purcell LA, Telenti A, Corti D
Nature (2021) 598 pp. 342-347 [ Pubmed: 34464958 DOI: doi:10.1038/s41586-021-03925-1 ]
Lempp FA, Soriaga LB, Montiel-Ruiz M, Benigni F, Noack J, Park YJ, Bianchi S, Walls AC, Bowen JE, Zhou J, Kaiser H, Joshi A, Agostini M, Meury M, Dellota Jr E, Jaconi S, Cameroni E, Martinez-Picado J, Vergara-Alert J, Izquierdo-Useros N, Virgin HW, Lanzavecchia A, Veesler D, Purcell LA, Telenti A, Corti D
Nature (2021) 598 pp. 342-347 [ Pubmed: 34464958 DOI: doi:10.1038/s41586-021-03925-1 ]
SARS-CoV-2 spike protein bound to the S2P6 and S2M11 Fab fragments
Pinto D, Sauer MM, Czudnochowski N, Low JS, Tortorici MA, Housley MP, Noack J, Walls AC, Bowen JE, Guarino B, Rosen LE, di Iulio J, Jerak J, Kaiser H, Islam S, Jaconi S, Sprugasci N, Culap K, Abdelnabi R, Foo C, Coelmont L, Bartha I, Bianchi S, Silacci-Fregni C, Bassi J, Marzi R, Vetti E, Cassotta A, Ceschi A, Ferrari P, Cippa PE, Giannini O, Ceruti S, Garzoni C, Riva A, Benigni F, Cameroni E, Piccoli L, Pizzuto MS, Smithey M, Hong D, Telenti A, Lempp FA, Neyts J, Havenar-Daughton C, Lanzavecchia A, Sallusto F, Snell G, Virgin HW, Beltramello M, Corti D, Veesler D
Science (2021) 373 pp. 1109-1116 [ Pubmed: 34344823 DOI: doi:10.1126/science.abj3321 ]
- S2m11 fab fragment (Complex from Homo sapiens)
- S2p6 and s2m11 fab fragments bound to the sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- S2p6 fab fragment (Complex from Homo sapiens)
SARS-CoV-2 S (B.1.429 / epsilon variant) + S2M11 + S2L20 Global Refinement
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 7n8h
Q-score: 0.594
McCallum M, Bassi J, De Marco A, Chen A, Walls AC, Di Iulio J, Tortorici MA, Navarro MJ, Silacci-Fregni C, Saliba C, Sprouse KR, Agostini M, Pinto D, Culap K, Bianchi S, Jaconi S, Cameroni E, Bowen JE, Tilles SW, Pizzuto MS, Guastalla SB, Bona G, Pellanda AF, Garzoni C, Van Voorhis WC, Rosen LE, Snell G, Telenti A, Virgin HW, Piccoli L, Corti D, Veesler D
Science (2021) 373 pp. 648-654 [ Pubmed: 34210893 DOI: doi:10.1126/science.abi7994 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s (b.1.429 / epsilon variant) bound to s2m11 and s2l20 fabs (Complex from Homo sapiens)
- S2l20 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2l20 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- S2m11 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)
- S2m11 fab light chain variable region (11 kDa, Protein from Homo sapiens)
SARS-CoV-2 S (B.1.429 / epsilon variant) + S2M11 + S2L20 (Local Refinement of the NTD/S2L20)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7n8i
Q-score: 0.582
McCallum M, Bassi J, De Marco A, Chen A, Walls AC, Di Iulio J, Tortorici MA, Navarro MJ, Silacci-Fregni C, Saliba C, Sprouse KR, Agostini M, Pinto D, Culap K, Bianchi S, Jaconi S, Cameroni E, Bowen JE, Tilles SW, Pizzuto MS, Guastalla SB, Bona G, Pellanda AF, Garzoni C, Van Voorhis WC, Rosen LE, Snell G, Telenti A, Virgin HW, Piccoli L, Corti D, Veesler D
Science (2021) 373 pp. 648-654 [ Pubmed: 34210893 DOI: doi:10.1126/science.abi7994 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s (b.1.429 / epsilon variant) bound to s2l20 fab (Complex from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2l20 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- S2l20 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)
SARS-CoV-2 S/S2M11/S2X333 Local Refinement
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7lxw
Q-score: 0.522
McCallum M, De Marco A, Lempp FA, Tortorici MA, Pinto D, Walls AC, Beltramello M, Chen A, Liu Z, Zatta F, Zepeda S, di Iulio J, Bowen JE, Montiel-Ruiz M, Zhou J, Rosen LE, Bianchi S, Guarino B, Fregni CS, Abdelnabi R, Foo SC, Rothlauf PW, Bloyet LM, Benigni F, Cameroni E, Neyts J, Riva A, Snell G, Telenti A, Whelan SPJ, Virgin HW, Corti D, Pizzuto MS, Veesler D
Cell (2021) 184 pp. 2332- [ Pubmed: 33761326 DOI: doi:10.1016/j.cell.2021.03.028 ]
- S2x333 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s hexapro bound to s2x333 fab (Complex from Homo sapiens)
- S2x333 fab light chain variable region (10 kDa, Protein from Homo sapiens)
SARS-CoV-2 S/S2M11/S2L28 Local Refinement
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7lxx
Q-score: 0.507
McCallum M, De Marco A, Lempp FA, Tortorici MA, Pinto D, Walls AC, Beltramello M, Chen A, Liu Z, Zatta F, Zepeda S, di Iulio J, Bowen JE, Montiel-Ruiz M, Zhou J, Rosen LE, Bianchi S, Guarino B, Fregni CS, Abdelnabi R, Foo SC, Rothlauf PW, Bloyet LM, Benigni F, Cameroni E, Neyts J, Riva A, Snell G, Telenti A, Whelan SPJ, Virgin HW, Corti D, Pizzuto MS, Veesler D
Cell (2021) 184 pp. 2332- [ Pubmed: 33761326 DOI: doi:10.1016/j.cell.2021.03.028 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S2l28 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)
- S2l28 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 s hexapro bound to s2l28 fab (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 S/S2M11/S2X333 Global Refinement
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7lxy
Q-score: 0.58
McCallum M, De Marco A, Lempp FA, Tortorici MA, Pinto D, Walls AC, Beltramello M, Chen A, Liu Z, Zatta F, Zepeda S, di Iulio J, Bowen JE, Montiel-Ruiz M, Zhou J, Rosen LE, Bianchi S, Guarino B, Fregni CS, Abdelnabi R, Foo SC, Rothlauf PW, Bloyet LM, Benigni F, Cameroni E, Neyts J, Riva A, Snell G, Telenti A, Whelan SPJ, Virgin HW, Corti D, Pizzuto MS, Veesler D
Cell (2021) 184 pp. 2332- [ Pubmed: 33761326 DOI: doi:10.1016/j.cell.2021.03.028 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s hexapro bound to s2x333 fab (Complex from Homo sapiens)
- S2x333 fab light chain variable region (10 kDa, Protein from Homo sapiens)
- S2x333 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Water (18 Da, Ligand)
- S2m11 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)
- S2m11 fab light chain variable region (11 kDa, Protein from Homo sapiens)
SARS-CoV-2 S/S2M11/S2L28 Global Refinement
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7lxz
Q-score: 0.54
McCallum M, De Marco A, Lempp FA, Tortorici MA, Pinto D, Walls AC, Beltramello M, Chen A, Liu Z, Zatta F, Zepeda S, di Iulio J, Bowen JE, Montiel-Ruiz M, Zhou J, Rosen LE, Bianchi S, Guarino B, Fregni CS, Abdelnabi R, Foo SC, Rothlauf PW, Bloyet LM, Benigni F, Cameroni E, Neyts J, Riva A, Snell G, Telenti A, Whelan SPJ, Virgin HW, Corti D, Pizzuto MS, Veesler D
Cell (2021) 184 pp. 2332- [ Pubmed: 33761326 DOI: doi:10.1016/j.cell.2021.03.028 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S2l28 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)
- S2l28 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 s hexapro bound to s2l28 fab (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2m11 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)
- S2m11 fab light chain variable region (11 kDa, Protein from Homo sapiens)
SARS-CoV-2 S/S2M11/S2M28 Local Refinement
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7ly0
Q-score: 0.529
McCallum M, De Marco A, Lempp FA, Tortorici MA, Pinto D, Walls AC, Beltramello M, Chen A, Liu Z, Zatta F, Zepeda S, di Iulio J, Bowen JE, Montiel-Ruiz M, Zhou J, Rosen LE, Bianchi S, Guarino B, Fregni CS, Abdelnabi R, Foo SC, Rothlauf PW, Bloyet LM, Benigni F, Cameroni E, Neyts J, Riva A, Snell G, Telenti A, Whelan SPJ, Virgin HW, Corti D, Pizzuto MS, Veesler D
Cell (2021) 184 pp. 2332- [ Pubmed: 33761326 DOI: doi:10.1016/j.cell.2021.03.028 ]
- S2m28 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s hexapro bound to s2m28 fab (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2m28 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)