DH270.6 Fab bound to the HIV-1 CH848 DE3 SOSIP
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8vgv
Q-score: 0.453
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ DOI: doi:10.1038/s41467-024-53120-9 Pubmed: 39489734 ]
- Antibody fab bound hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
- Ch848 de3 sosip gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Ch848 de3 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Dh270.6 antibody fab light chain (11 kDa, Protein from Homo sapiens)
- Dh270.6 antibody fab heavy chain (14 kDa, Protein from Homo sapiens)
VRC01 Fab bound to the HIV-1 CH848 DE3 SOSIP
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8vgw
Q-score: 0.426
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ DOI: doi:10.1038/s41467-024-53120-9 Pubmed: 39489734 ]
- Antibody fab bound hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
- Ch848 de3 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vrc01 fab light chain (11 kDa, Protein from Homo sapiens)
- Vrc01 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Ch848 de3 sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP
Resolution: 4.08 Å
EM Method: Single-particle
Fitted PDBs: 8vh1
Q-score: 0.404
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ DOI: doi:10.1038/s41467-024-53120-9 Pubmed: 39489734 ]
- Antibody fab bound hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
- Ch235.i60 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Ch505.m5 sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Ch505.m5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Ch235.i60 fab light chain (23 kDa, Protein from Homo sapiens)
CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP
Resolution: 4.31 Å
EM Method: Single-particle
Fitted PDBs: 8vh2
Q-score: 0.32
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ DOI: doi:10.1038/s41467-024-53120-9 Pubmed: 39489734 ]
- Antibody fab bound hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
- Ch505.m5.g458y sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Ch235.12 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ch235.12 fab light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)
CH505.M5.G458Y CE2 Design SOSIP
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8vh3
Q-score: 0.433
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ DOI: doi:10.1038/s41467-024-53120-9 Pubmed: 39489734 ]
- Ch505.ce2 sosip gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Ch505.ce2 sosip gp41 (16 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
Williams WB, Alam SM, Ofek G, Erdmann N, Montefiori DC, Seaman MS, Wagh K, Korber B, Edwards RJ, Mansouri K, Eaton A, Cain DW, Martin M, Hwang J, Arus-Altuz A, Lu X, Cai F, Jamieson N, Parks R, Barr M, Foulger A, Anasti K, Patel P, Sammour S, Parsons RJ, Huang X, Lindenberger J, Fetics S, Janowska K, Niyongabo A, Janus BM, Astavans A, Fox CB, Mohanty I, Evangelous T, Chen Y, Berry M, Kirshner H, Van Itallie E, Saunders KO, Wiehe K, Cohen KW, McElrath MJ, Corey L, Acharya P, Walsh SR, Baden LR, Haynes BF
Cell (2024) 187 pp. 2919-2934.e20 [ DOI: doi:10.1016/j.cell.2024.04.033 Pubmed: 38761800 ]
- Dh1317.4 heavy chain (Protein from Homo sapiens)
- Complex of jrfl.sosip.v6 with dh1317.4, vrc01 and pgt145 (450 MDa, Complex from Homo sapiens)
- Dh1317.4 light chain (Protein from Homo sapiens)
- Jrfl.sosip.v6 (Protein from Homo sapiens)
CryoEM structure of VRC01-CH848.0358.80
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 8sal
Q-score: 0.235
Henderson R, Zhou Y, Stalls V, Wiehe K, Saunders KO, Wagh K, Anasti K, Barr M, Parks R, Alam SM, Korber B, Haynes BF, Bartesaghi A, Acharya P
Nat Commun (2023) 14 pp. 2782-2782 [ Pubmed: 37188681 DOI: doi:10.1038/s41467-023-38108-1 ]
- Vcr01 variable light chain (11 kDa, Protein from Homo sapiens)
- Ch0848.3.d0358.80.06chim.ds.6r.sosip gp41 (17 kDa, Protein from HIV-1 06TG.HT008)
- Vrc01-ch848.0358.80 (Complex from Homo sapiens)
- Ch0848.3.d0358.80.06chim.ds.6r.sosip gp120 (53 kDa, Protein from HIV-1 06TG.HT008)
- Vcr01 variable heavy chain (13 kDa, Protein from Homo sapiens)
CryoEM structure of VRC01-CH848.0836.10
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8san
Q-score: 0.349
Henderson R, Zhou Y, Stalls V, Wiehe K, Saunders KO, Wagh K, Anasti K, Barr M, Parks R, Alam SM, Korber B, Haynes BF, Bartesaghi A, Acharya P
Nat Commun (2023) 14 pp. 2782-2782 [ Pubmed: 37188681 DOI: doi:10.1038/s41467-023-38108-1 ]
- Ch848.0836.10 gp120 (51 kDa, Protein from HIV-1 06TG.HT008)
- Ch848.0836.10 gp41 (17 kDa, Protein from HIV-1 06TG.HT008)
- Vcr01 variable light chain (23 kDa, Protein from Homo sapiens)
- Vcr01 variable heavy chain (24 kDa, Protein from Homo sapiens)
- Vrc01-ch848.0836.10 (Complex from Homo sapiens)
CryoEM structure of DH270.6-CH848.0526.25
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8saq
Q-score: 0.433
Henderson R, Zhou Y, Stalls V, Wiehe K, Saunders KO, Wagh K, Anasti K, Barr M, Parks R, Alam SM, Korber B, Haynes BF, Bartesaghi A, Acharya P
Nat Commun (2023) 14 pp. 2782-2782 [ Pubmed: 37188681 DOI: doi:10.1038/s41467-023-38108-1 ]
- Dh270.6-ch848.0526.25 (Complex from Homo sapiens)
- Ch848.0526.25 gp41 (17 kDa, Protein from HIV-1 06TG.HT008)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ch848.0526.25 gp120 (54 kDa, Protein from HIV-1 06TG.HT008)
- Dh270.6 variable heavy chain (14 kDa, Protein from Homo sapiens)
- Dh270.6 variable light chain (11 kDa, Protein from Homo sapiens)
CryoEM structure of DH270.6-CH848.10.17
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 8sar
Q-score: 0.402
Henderson R, Zhou Y, Stalls V, Wiehe K, Saunders KO, Wagh K, Anasti K, Barr M, Parks R, Alam SM, Korber B, Haynes BF, Bartesaghi A, Acharya P
Nat Commun (2023) 14 pp. 2782-2782 [ Pubmed: 37188681 DOI: doi:10.1038/s41467-023-38108-1 ]
- Ch848.10.17 gp41 (14 kDa, Protein from HIV-1 06TG.HT008)
- Ch848.10.17 gp120 (51 kDa, Protein from HIV-1 06TG.HT008)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh270.6-ch848.10.17 (Complex from Homo sapiens)
- Dh270.6 variable heavy chain (14 kDa, Protein from Homo sapiens)
- Dh270.6 variable light chain (11 kDa, Protein from Homo sapiens)