Cryo-EM structure of activated-form DNA-PK (complex VI)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7k0y
Q-score: 0.441
Chen X, Xu X, Chen Y, Cheung JC, Wang H, Jiang J, de Val N, Fox T, Gellert M, Yang W
Mol Cell (2021) 81 pp. 801-810.e3 [ Pubmed: 33385326 DOI: doi:10.1016/j.molcel.2020.12.015 ]
- Dna (5'-d(*gp*cp*ap*tp*gp*cp*tp*cp*tp*ap*cp*tp*gp*cp*tp*tp*cp*gp*ap*tp*ap*tp*cp*g)-3') (7 kDa, DNA from synthetic construct)
- Dna-pk (Complex from Homo sapiens)
- Dna (5'-d(*ap*ap*gp*cp*ap*gp*tp*ap*gp*ap*gp*cp*a)-3') (4 kDa, DNA from synthetic construct)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
CryoEM structure of activated-form FATKIN domain of DNA-PK
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7k10
Q-score: 0.494
Chen X, Xu X, Chen Y, Cheung JC, Wang H, Jiang J, de Val N, Fox T, Gellert M, Yang W
Mol Cell (2021) 81 pp. 801-810.e3 [ Pubmed: 33385326 DOI: doi:10.1016/j.molcel.2020.12.015 ]
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- Fatkin 2 (Complex from Homo sapiens)
CryoEM structure of inactivated-form FATKIN domain of DNA-PK
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 7k11
Q-score: 0.5
Chen X, Xu X, Chen Y, Cheung JC, Wang H, Jiang J, de Val N, Fox T, Gellert M, Yang W
Mol Cell (2021) 81 pp. 801-810.e3 [ Pubmed: 33385326 DOI: doi:10.1016/j.molcel.2020.12.015 ]
- Fatkin (Complex from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
CryoEM structure of DNA-PK catalytic subunit complexed with DNA (Complex I)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7k19
Q-score: 0.339
Chen X, Xu X, Chen Y, Cheung JC, Wang H, Jiang J, de Val N, Fox T, Gellert M, Yang W
Mol Cell (2021) 81 pp. 801-810.e3 [ Pubmed: 33385326 DOI: doi:10.1016/j.molcel.2020.12.015 ]
- Complex i (Complex from Homo sapiens)
- Dna (5'-d(*ap*ap*gp*cp*ap*gp*tp*ap*gp*ap*gp*cp*ap*tp*gp*c)-3') (4 kDa, DNA from synthetic construct)
- Dna (5'-d(*gp*cp*ap*tp*gp*cp*tp*cp*tp*ap*cp*tp*gp*cp*tp*tp*cp*gp*ap*tp*ap*tp*cp*g)-3') (7 kDa, DNA from synthetic construct)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
CryoEM structure of DNA-PK catalytic subunit complexed with DNA (Complex II)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7k1b
Q-score: 0.336
Chen X, Xu X, Chen Y, Cheung JC, Wang H, Jiang J, de Val N, Fox T, Gellert M, Yang W
Mol Cell (2021) 81 pp. 801-810.e3 [ Pubmed: 33385326 DOI: doi:10.1016/j.molcel.2020.12.015 ]
- Complex ii (Complex from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- Dna (5'-d(p*ap*ap*gp*cp*ap*gp*tp*ap*gp*ap*gp*cp*ap*tp*gp*c)-3') (4 kDa, DNA from synthetic construct)
- Dna (5'-d(p*gp*cp*ap*tp*gp*cp*tp*cp*tp*ap*cp*tp*gp*cp*tp*tp*cp*gp*ap*tp*ap*tp*cp*g)-3') (7 kDa, DNA from synthetic construct)
CryoEM structure of inactivated-form DNA-PK (Complex III)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7k1j
Q-score: 0.407
Chen X, Xu X, Chen Y, Cheung JC, Wang H, Jiang J, de Val N, Fox T, Gellert M, Yang W
Mol Cell (2021) 81 pp. 801-810.e3 [ Pubmed: 33385326 DOI: doi:10.1016/j.molcel.2020.12.015 ]
- Dna (5'-d(*gp*cp*ap*tp*gp*cp*tp*cp*tp*ap*cp*tp*gp*cp*tp*tp*cp*gp*ap*tp*ap*tp*cp*g)-3') (7 kDa, DNA from synthetic construct)
- Dna (5'-d(*ap*ap*gp*cp*ap*gp*tp*ap*gp*ap*gp*cp*a)-3') (4 kDa, DNA from synthetic construct)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Complex iii (Complex from Homo sapiens)
CryoEM structure of inactivated-form DNA-PK (Complex IV)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7k1k
Q-score: 0.378
Chen X, Xu X, Chen Y, Cheung JC, Wang H, Jiang J, de Val N, Fox T, Gellert M, Yang W
Mol Cell (2021) 81 pp. 801-810.e3 [ Pubmed: 33385326 DOI: doi:10.1016/j.molcel.2020.12.015 ]
- Dna (5'-d(*gp*cp*ap*tp*gp*cp*tp*cp*tp*ap*cp*tp*gp*cp*tp*tp*cp*gp*ap*tp*ap*tp*cp*g)-3') (7 kDa, DNA from synthetic construct)
- Dna-pk (Complex from Homo sapiens)
- Dna (5'-d(*ap*ap*gp*cp*ap*gp*tp*ap*gp*ap*gp*cp*a)-3') (4 kDa, DNA from synthetic construct)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
CryoEM structure of inactivated-form DNA-PK (Complex V)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7k1n
Q-score: 0.417
Chen X, Xu X, Chen Y, Cheung JC, Wang H, Jiang J, de Val N, Fox T, Gellert M, Yang W
Mol Cell (2021) 81 pp. 801-810.e3 [ Pubmed: 33385326 DOI: doi:10.1016/j.molcel.2020.12.015 ]
- Dna (5'-d(p*ap*ap*gp*cp*ap*gp*tp*ap*gp*ap*gp*cp*a)-3') (4 kDa, DNA from synthetic construct)
- Complex v (Complex from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Dna (5'-d(p*gp*cp*ap*tp*gp*cp*tp*cp*tp*ap*cp*tp*gp*cp*tp*tp*cp*gp*ap*tp*ap*tp*cp*g)-3') (7 kDa, DNA from synthetic construct)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6n7i
Q-score: 0.483
Gao Y, Cui Y, Fox T, Lin S, Wang H, de Val N, Zhou ZH, Yang W
Science (2019) 363 [ Pubmed: 30679383 DOI: doi:10.1126/science.aav7003 ]
- Water (18 Da, Ligand)
- Dna (25-mer) (7 kDa, DNA from Enterobacteria phage T7)
- Bacteriophage t7 gene product 4 (gp4) helicase primase dna complex with five helicase subunits ordered (Complex from Enterobacteria phage T7)
- Magnesium ion (24 Da, Ligand)
- Thymidine-5'-triphosphate (482 Da, Ligand)
- Dna primase/helicase (62 kDa, Protein from Enterobacteria phage T7)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6n7n
Q-score: 0.421
Gao Y, Cui Y, Fox T, Lin S, Wang H, de Val N, Zhou ZH, Yang W
Science (2019) 363 [ Pubmed: 30679383 DOI: doi:10.1126/science.aav7003 ]
- Magnesium ion (24 Da, Ligand)
- Bacteriophage t7 gene product 4 (gp4) helicase primase dna complex i (Complex from Enterobacteria phage T7)
- Thymidine-5'-triphosphate (482 Da, Ligand)
- Dna primase/helicase (62 kDa, Protein from Enterobacteria phage T7)
- Dna (5'-d(p*tp*tp*tp*tp*tp*tp*tp*tp*tp*tp*tp*tp*tp*tp*t)-3') (4 kDa, DNA from Enterobacteria phage T7)