Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ew2
Q-score: 0.441
Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z
Cell Res (2022) 32 pp. 218-221 [ DOI: doi:10.1038/s41422-021-00567-w Pubmed: 34545189 ]
- (2~{s})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol (387 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 (46 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 complexed with gi protein (Complex from Homo sapiens)
Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ew3
Q-score: 0.51
Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z
Cell Res (2022) 32 pp. 218-221 [ DOI: doi:10.1038/s41422-021-00567-w Pubmed: 34545189 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 (46 kDa, Protein from Homo sapiens)
- (2s,3r,4e)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (379 Da, Ligand)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Sphingosine 1-phosphate receptor 3 complexed with gi protein (Complex from Homo sapiens)
Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7ew4
Q-score: 0.457
Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z
Cell Res (2022) 32 pp. 218-221 [ DOI: doi:10.1038/s41422-021-00567-w Pubmed: 34545189 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- N,n-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide (316 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 (46 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Sphingosine 1-phosphate receptor 3 complexed with gi protein (Complex from Homo sapiens)