Cryo-EM structure of opioid receptor with biased agonist
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8y45
Q-score: 0.407
Cheng L, Miao Z, Liu S, Li Z, Fu H, Xu C, Hu S, Zhao C, Liu Y, Zhao T, Liu W, Wang H, Liu R, Yan W, Tang X, Liu J, Shao Z, Ke B
Nat Commun (2024) 15 pp. 8284-8284 [ Pubmed: 39333070 DOI: doi:10.1038/s41467-024-52601-1 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Delta-type opioid receptor (36 kDa, Protein from Homo sapiens)
- ~{n},~{n}-diethyl-4-(5-oxidanylspiro[chromene-2,4'-piperidine]-4-yl)benzamide (392 Da, Ligand)
- Cryo-em structure of opioid receptor with biased agonist (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of compound 9n bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8jhy
Q-score: 0.538
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- 7-methyl-n-[(2r)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide (428 Da, Ligand)
- Hca2 in complex with gi heterotrimer (Complex)
- Scfv16 (Complex from Mus musculus)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of compound 9n and niacin bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8jii
Q-score: 0.521
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- 7-methyl-n-[(2r)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide (428 Da, Ligand)
- Nicotinic acid (123 Da, Ligand)
- Hca2 in complex with gi heterotrimer (Complex)
- Scfv16 (Complex from Mus musculus)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of niacin bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8jil
Q-score: 0.476
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- Nicotinic acid (123 Da, Ligand)
- Scfv16 (Complex from Mus musculus)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Niacin-bound hcar2 in complex with gi heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of MMF bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8jim
Q-score: 0.509
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- Hca2 in complex with gi heterotrimer (Complex)
- Scfv16 (Complex from Mus musculus)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- (2z)-4-methoxy-4-oxobut-2-enoic acid (130 Da, Ligand)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ew2
Q-score: 0.441
Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z
Cell Res (2022) 32 pp. 218-221 [ DOI: doi:10.1038/s41422-021-00567-w Pubmed: 34545189 ]
- (2~{s})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol (387 Da, Ligand)
- Sphingosine 1-phosphate receptor 3 complexed with gi protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ew3
Q-score: 0.51
Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z
Cell Res (2022) 32 pp. 218-221 [ DOI: doi:10.1038/s41422-021-00567-w Pubmed: 34545189 ]
- Palmitic acid (256 Da, Ligand)
- Sphingosine 1-phosphate receptor 3 complexed with gi protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (2s,3r,4e)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (379 Da, Ligand)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7ew4
Q-score: 0.457
Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z
Cell Res (2022) 32 pp. 218-221 [ DOI: doi:10.1038/s41422-021-00567-w Pubmed: 34545189 ]
- N,n-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide (316 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Sphingosine 1-phosphate receptor 3 complexed with gi protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)