Omicron BA.4/5 SARS-CoV-2 S in complex with TH027 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yve
Q-score: 0.47
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Th027 fab (Complex from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Omicron ba.5 sars-cov-2 s in complex with th027 fab (Complex)
- Th027 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Th027 fab light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Omicron BA.4/5 SARS-CoV-2 S in complex with TH132 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yvg
Q-score: 0.384
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- Th132 fab heavy chain (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Omicron ba.4/5 sars-cov-2 s in complex with th027 fab (Complex)
- Th027 fab (Complex from Homo sapiens)
- Th132 fab light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Omicron ba.4/5 sars-cov-2 s (Complex from Severe acute respiratory syndrome coronavirus 2)
Omicron BA.4/5 SARS-CoV-2 S in complex with TH236 Fab
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7yvi
Q-score: 0.414
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Omicron ba.4/5 sars-cov-2 s in complex with th027 fab (Complex)
- Th027 fab (Complex from Homo sapiens)
- Th236 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Th236 fab light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Omicron ba.4/5 sars-cov-2 s (Complex from Severe acute respiratory syndrome coronavirus 2)
Omicron BA.4/5 SARS-CoV-2 S in complex with TH272 Fab
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7yvk
Q-score: 0.428
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Omicron ba.4/5 sars-cov-2 s in complex with th027 fab (Complex)
- Th027 fab (Complex from Homo sapiens)
- Th272 fab light chain (11 kDa, Protein from Homo sapiens)
- Th272 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Omicron ba.4/5 sars-cov-2 s (Complex from Severe acute respiratory syndrome coronavirus 2)
Omicron BA.4/5 SARS-CoV-2 S in complex with TH281 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yvn
Q-score: 0.368
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Omicron ba.4/5 sars-cov-2 s in complex with th281 fab (Complex)
- Th281 fab (Complex from Homo sapiens)
- Th281 fab heavy chain (12 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Th281 fab light chain (11 kDa, Protein from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 s (Complex from Severe acute respiratory syndrome coronavirus 2)
Omicron BA.4/5 SARS-CoV-2 S in complex with TH027/132 Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7yvo
Q-score: 0.349
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- Th132 fab heavy chain (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- H132, h027 fab (Complex from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 s in complex with th027 fab (Complex)
- Th27 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Th27 fab light chain (11 kDa, Protein from Homo sapiens)
- Th132 fab light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Omicron ba.4/5 sars-cov-2 s (Complex from Severe acute respiratory syndrome coronavirus 2)
Omicron BA.4/5 SARS-CoV-2 S in complex with TH272/281 Fab
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7yvp
Q-score: 0.325
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- Omicron ba.4/5 sars-cov-2 s in complex with th272/281 fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Th272 fab light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Th272/281 fab (Complex from Homo sapiens)
- Th281 fab heavy chain (12 kDa, Protein from Homo sapiens)
- Th272 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Th281 fab light chain (11 kDa, Protein from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 s (Complex from Severe acute respiratory syndrome coronavirus 2)
Omicron BA.4/5 SARS-CoV-2 S in complex with TH003 Fab
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8gou
Q-score: 0.362
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Th003 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Th003 fab light chain (11 kDa, Protein from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 s in complex with th003 fab (Complex)
- Th003 fab (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 RdRP catalytic complex with T33-1 RNA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7dte
Q-score: 0.528
Wu J, Wang H, Liu Q, Li R, Gao Y, Fang X, Zhong Y, Wang M, Wang Q, Rao Z, Gong P
Cell Rep (2021) 37 pp. 109882-109882 [ Pubmed: 34653416 DOI: doi:10.1016/j.celrep.2021.109882 ]
- Rna (Complex)
- Zinc ion (65 Da, Ligand)
- Sars-cov-2 rna-dependent rna polymerase catalytic complex (Complex from Severe acute respiratory syndrome coronavirus 2)
- Rna-directed rna polymerase (108 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna (33-mer) (10 kDa, RNA from Foot-and-mouth disease virus)
- Sars-cov-2 rna-dependent rna polymerase (Complex)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 8 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna (57-mer) (18 kDa, RNA from Foot-and-mouth disease virus)
COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7bzf
Q-score: 0.47
Wang Q, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, Ge J, Sun Q, Yang X, Xu W, Liu Z, Yang H, Lou Z, Jiang B, Guddat LW, Gong P, Rao Z
Cell (2020) 182 pp. 417-428.e13 [ DOI: doi:10.1016/j.cell.2020.05.034 Pubmed: 32526208 ]
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase (108 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 8 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna (5'-r(*up*gp*up*up*cp*gp*ap*cp*gp*ap*cp*ap*cp*a)-3') (4 kDa, RNA from Foot-and-mouth disease virus)
- Structure of covid-19 rna-dependent rna polymerase in complex with rna (155 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Rna (31-mer) (10 kDa, RNA from Foot-and-mouth disease virus)