Cannabinoid Receptor 1-G Protein Complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8ghv
Q-score: 0.569
Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B
Nat Commun (2023) 14 pp. 2672-2672 [ Pubmed: 37160876 DOI: doi:10.1038/s41467-023-37864-4 ]
- (5z,8z,11z,13s,14z)-n-[(2r)-1-hydroxypropan-2-yl]-13-methylicosa-5,8,11,14-tetraenamide (375 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gi g protein heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cannabinoid receptor 1 (Complex from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cannabinoid receptor 1 in complex with gi protein heterotrimer and scfv16 (Complex from Homo sapiens)
- Cannabinoid receptor 1 (55 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
Cannabinoid Receptor 1/G protein complex, Global Refinement
Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B
Nat Commun (2023) 14 pp. 2672-2672 [ Pubmed: 37160876 DOI: doi:10.1038/s41467-023-37864-4 ]
Cannabinoid Receptor 1/G protein complex, local refinement
Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B
Nat Commun (2023) 14 pp. 2672-2672 [ Pubmed: 37160876 DOI: doi:10.1038/s41467-023-37864-4 ]
C6-guano bound Mu Opioid Receptor-Gi Protein Complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7u2k
Q-score: 0.527
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S
Nature (2023) 613 pp. 767-774 [ DOI: doi:10.1038/s41586-022-05588-y Pubmed: 36450356 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- N-(6-carbamimidamidohexyl)-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide (401 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Mu-type opioid receptor (39 kDa, Protein from Mus musculus)
- C6guano bound mu opioid receptor-gi protein complex (Complex from Homo sapiens)
FH210 bound Mu Opioid Receptor-Gi Protein Complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7scg
Q-score: 0.575
Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hubner H, Skiniotis G, Kobilka BK, Gmeiner P
Angew Chem Int Ed Engl (2022) 61 pp. e202200269-e202200269 [ DOI: doi:10.1002/anie.202200269 Pubmed: 35385593 ]
- Fh210 bound mu opioid receptor-gi protein complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (2e)-n-[(2s)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-(naphthalen-1-yl)prop-2-enamide (374 Da, Ligand)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Mu-type opioid receptor (39 kDa, Protein from Mus musculus)