Structure of HCoV-HKU1A spike in the functionally anchored-3up conformation with 3TMPRSS2
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8y7x
Q-score: 0.331
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
- Hku1a-tmprss2 complex (Complex from Human coronavirus HKU1)
- Spike glycoprotein (141 kDa, Protein from Human coronavirus HKU1 (isolate N1))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Local structure of HCoV-HKU1A spike in complex with TMPRSS2 and glycan
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8y7y
Q-score: 0.577
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- Methyl 9-o-acetyl-5-acetamido-3,5-dideoxy-d-glycero-alpha-d-galacto-non-2-ulopyranosidonic acid (365 Da, Ligand)
- Hku1a-tmprss2 complex (Complex from Human coronavirus HKU1)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Human coronavirus HKU1 (isolate N1))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of HCoV-HKU1C spike in the functionally anchored-1up conformation with 1TMPRSS2
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8y87
Q-score: 0.355
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- Hku1b-tmprss2 complex (Complex from Human coronavirus HKU1)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1 (isolate N5))
Structure of HCoV-HKU1C spike in the functionally anchored-2up conformation with 2TMPRSS2
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8y88
Q-score: 0.37
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- Hku1a-tmprss2 complex (Complex from Human coronavirus HKU1)
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 2TMPRSS2
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8y89
Q-score: 0.296
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hku1c-tmprss2 complex (Complex from Human coronavirus HKU1)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1)
Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 3TMPRSS2
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8y8a
Q-score: 0.308
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1 (isolate N5))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
- Hku1b-tmprss2 complex (Complex from Human coronavirus HKU1)
Local structure of HCoV-HKU1C spike in complex with TMPRSS2 and glycan
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8y8b
Q-score: 0.597
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- Hku1c-tmprss2 complex (Complex from Human coronavirus HKU1)
- Methyl 9-o-acetyl-5-acetamido-3,5-dideoxy-d-glycero-alpha-d-galacto-non-2-ulopyranosidonic acid (365 Da, Ligand)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1 (isolate N5))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Omicron BA.4/5 SARS-CoV-2 S in complex with TH027 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yve
Q-score: 0.47
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ Pubmed: 37322000 DOI: doi:10.1038/s41467-023-39267-x ]
- Omicron ba.5 sars-cov-2 s in complex with th027 fab (Complex)
- Omicron ba.4/5 sars-cov-2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Th027 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Th027 fab (Complex from Homo sapiens)
- Th027 fab light chain (11 kDa, Protein from Homo sapiens)
Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH027 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yvf
Q-score: 0.518
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- Th027 fab light chain (11 kDa, Protein from Homo sapiens)
- Th027 fab (Complex from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 s (Complex from Severe acute respiratory syndrome coronavirus 2)
- Omicron ba.5 sars-cov-2 s rbd in complex with th027 fab (Complex)
- Th027 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Omicron BA.4/5 SARS-CoV-2 S in complex with TH132 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yvg
Q-score: 0.384
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- Omicron ba.4/5 sars-cov-2 s in complex with th027 fab (Complex)
- Th132 fab light chain (11 kDa, Protein from Homo sapiens)
- Th027 fab (Complex from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 s (Complex from Severe acute respiratory syndrome coronavirus 2)
- Th132 fab heavy chain (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)