Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8jiz
Q-score: 0.335
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ DOI: doi:10.1038/s41594-024-01387-3 Pubmed: 39227720 ]
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
- Fab5f6 heavy chain (27 kDa, Protein from Homo sapiens)
- Fab5f6 light chain (25 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of glun1-2a nmdar in complex with human fab23 (Cell from Homo sapiens)
Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in one fab bind conformation
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 8jj0
Q-score: 0.25
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ DOI: doi:10.1038/s41594-024-01387-3 Pubmed: 39227720 ]
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
- Fab5f6 light chain (25 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab5f6 heavy chain (27 kDa, Protein from Homo sapiens)
- Cryo-em structure of glun1-2a nmdar in complex with human fab23 (Cell from Homo sapiens)
Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in two fab conformation
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 8jj1
Q-score: 0.314
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ DOI: doi:10.1038/s41594-024-01387-3 Pubmed: 39227720 ]
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
- Fab 2g7 light chain (25 kDa, Protein from Homo sapiens)
- Cryo-em structure of glun1-2a nmdar in complex with human fab28 (Cell from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab 2g7 heavy chain (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in one fab conformation
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8jj2
Q-score: 0.274
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ DOI: doi:10.1038/s41594-024-01387-3 Pubmed: 39227720 ]
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
- Fab2g7 light chain (25 kDa, Protein from Homo sapiens)
- Fab2g7 heavy chain (26 kDa, Protein from Homo sapiens)
- Cryo-em structure of glun1-2a nmdar in complex with human fab28 (Cell from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cyro-EM structure of HCMV glycoprotein B in complex with 1B03 Fab
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 7yrn
Q-score: 0.375
To Be Published
- 1b03 fab antibody light chain (23 kDa, Protein from Homo sapiens)
- Hcmv glycoprotein b in complex with 1b03 fab (Complex)
- 1b03 fab (Complex from Homo sapiens)
- Hcmv glycoprotein b (Complex from Human betaherpesvirus 5)
- 1b03 fab antibody heavy chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein b (83 kDa, Protein from Human betaherpesvirus 5)
Structure of the human GluN1/GluN2A NMDA receptor in the glycine/CPP bound state
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7eoq
Q-score: 0.288
Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S
Neuron (2021) 109 pp. 2443-2456.e5 [ DOI: doi:10.1016/j.neuron.2021.05.031 Pubmed: 34186027 ]
- Glutamate receptor ionotropic, nmda 2a (95 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- (2r)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (252 Da, Ligand)
- Structure of the human glun1/glun2a nmda receptor in the glycine/cpp bound state (Complex from Homo sapiens)
Structure of the human GluN1/GluN2A NMDA receptor in the glycine/glutamate/GNE-6901 bound state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7eor
Q-score: 0.284
Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S
Neuron (2021) 109 pp. 2443-2456.e5 [ DOI: doi:10.1016/j.neuron.2021.05.031 Pubmed: 34186027 ]
- Glutamate receptor ionotropic, nmda 2a (95 kDa, Protein from Homo sapiens)
- 7-[(4-fluoranylphenoxy)methyl]-3-[(1~{r},2~{r})-2-(hydroxymethyl)cyclopropyl]-2-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one (360 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of the human glun1/glun2a nmda receptor in the glycine/glutamate/gne-6901 bound state (Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
Structure of the human GluN1/GluN2A NMDA receptor in the glycine/glutamate bound state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7eos
Q-score: 0.306
Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S
Neuron (2021) 109 pp. 2443-2456.e5 [ DOI: doi:10.1016/j.neuron.2021.05.031 Pubmed: 34186027 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2a (95 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Structure of the human glun1/glun2a nmda receptor in the glycine/glutamate bound state (Complex from Homo sapiens)
Structure of the human GluN1/GluN2A NMDA receptor in the CGP-78608/glutamate bound state
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7eot
Q-score: 0.281
Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S
Neuron (2021) 109 pp. 2443-2456.e5 [ Pubmed: 34186027 DOI: doi:10.1016/j.neuron.2021.05.031 ]
- Glutamate receptor ionotropic, nmda 2a (95 kDa, Protein from Homo sapiens)
- Structure of the human glun1/glun2a nmda receptor in the cgp-78608/glutamate bound state (Complex from Homo sapiens)
- [(1s)-1-[[7-bromanyl-2,3-bis(oxidanylidene)-1,4-dihydroquinoxalin-5-yl]methylamino]ethyl]phosphonic acid (378 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the human GluN1/GluN2A NMDA receptor in the glycine/glutamate/GNE-6901/9-AA bound state
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7eou
Q-score: 0.259
Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S
Neuron (2021) 109 pp. 2443-2456.e5 [ Pubmed: 34186027 DOI: doi:10.1016/j.neuron.2021.05.031 ]
- Glutamate receptor ionotropic, nmda 2a (95 kDa, Protein from Homo sapiens)
- 7-[(4-fluoranylphenoxy)methyl]-3-[(1~{r},2~{r})-2-(hydroxymethyl)cyclopropyl]-2-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one (360 Da, Ligand)
- 9-aminoacridine (195 Da, Ligand)
- Structure of the human glun1/glun2a nmda receptor in the glycine/glutamate/gne-6901/9-aa bound state (Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)