5-HT1A-Gi in complex with compound (R)-IHCH-7179
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jt6
Q-score: 0.542
Chen Z, Yu J, Wang H, Xu P, Fan L, Sun F, Huang S, Zhang P, Huang H, Gu S, Zhang B, Zhou Y, Wan X, Pei G, Xu HE, Cheng J, Wang S
Cell (2024) 187 pp. 2194-2208.e22 [ DOI: doi:10.1016/j.cell.2024.02.034 Pubmed: 38552625 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 1-(4-fluorophenyl)-4-[(7r)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one (377 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a (60 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 5-ht1a-gi in complex with compound (r)-ihch-7179 (Complex from Homo sapiens)
Ulotaront(SEP-363856)-bound mTAAR1-Gs protein complex
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8jlk
Q-score: 0.387
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Mgs (41 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- T1am-bound htaar1 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (Complex from Mus musculus)
- Gs heterotrimer (Complex from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (50 kDa, Protein from Mus musculus)
Ulotaront(SEP-363856)-bound hTAAR1-Gs protein complex
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8jlo
Q-score: 0.473
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Sep-bound htaar1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Htaar1-bound sep363856 in complex with gs heterotrimer (Complex)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
AMPH-bound hTAAR1-Gs protein complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8jso
Q-score: 0.439
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Mgs (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- (2s)-1-phenylpropan-2-amine (135 Da, Ligand)
- Htaar1-bound amphetamine in complex with gs heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Amphetamine-bound htaar1 (Complex from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Gs heterotrimer (Complex from Homo sapiens)
Ulotaront(SEP-363856)-bound Serotonin 1A (5-HT1A) receptor-Gi complex
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 8jsp
Q-score: 0.411
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (35 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (4 kDa, Protein from Homo sapiens)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (Complex from Mus musculus)
- 5-hydroxytryptamine receptor 1a (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 5ht1a in complex with gi heterotrimer (Complex from Homo sapiens)
Cryo-EM structure of compound 9n bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8jhy
Q-score: 0.538
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 7-methyl-n-[(2r)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide (428 Da, Ligand)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Hca2 in complex with gi heterotrimer (Complex)
- Scfv16 (28 kDa, Protein from Mus musculus)
Cryo-EM structure of compound 9n and niacin bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8jii
Q-score: 0.521
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 7-methyl-n-[(2r)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide (428 Da, Ligand)
- Nicotinic acid (123 Da, Ligand)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Hca2 in complex with gi heterotrimer (Complex)
- Scfv16 (28 kDa, Protein from Mus musculus)
Cryo-EM structure of niacin bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8jil
Q-score: 0.476
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Nicotinic acid (123 Da, Ligand)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Niacin-bound hcar2 in complex with gi heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
Cryo-EM structure of MMF bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8jim
Q-score: 0.509
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Cholesterol (386 Da, Ligand)
- (2z)-4-methoxy-4-oxobut-2-enoic acid (130 Da, Ligand)
- Hca2 in complex with gi heterotrimer (Complex)
- Scfv16 (28 kDa, Protein from Mus musculus)