3-Methylcrotonyl-CoA Carboxylase in MCCD state with Acetyl CoA
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Dodecamer of human mcc (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Acetyl coenzyme *a (809 Da, Ligand)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state with MCoA
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8jxm
Q-score: 0.289
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Dodecamer of human mcc (Complex from Homo sapiens)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{s},3~{s},4~{s},5~{s})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate (849 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state with MCoA
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8jxn
Q-score: 0.382
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ Pubmed: 39223421 DOI: doi:10.1038/s41594-024-01379-3 ]
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{s},3~{s},4~{s},5~{s})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate (849 Da, Ligand)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Dodecamer of human mcc (Complex from Homo sapiens)
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8jaw
Q-score: 0.506
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ Pubmed: 39223421 DOI: doi:10.1038/s41594-024-01379-3 ]
- Dodecamer of human mcc (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8j7d
Q-score: 0.435
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Human mcc (Complex from Homo sapiens)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8j4z
Q-score: 0.418
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Heterododecamer of human mcc (Complex from Homo sapiens)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{s},3~{s},4~{s},5~{s})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate (849 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
Resolution: 5.63 Å
EM Method: Single-particle
Fitted PDBs: 8hwl
Q-score: 0.062
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2024) [ Pubmed: 39223421 DOI: doi:10.1038/s41594-024-01379-3 ]
- Pyruvate carboxylase (Complex from Homo sapiens)
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
Human propionyl-coenzyme A carboxylase
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7ybu
Q-score: 0.54
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2024) [ Pubmed: 39223421 DOI: doi:10.1038/s41594-024-01379-3 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Propionyl-coa carboxylase alpha chain, mitochondrial (80 kDa, Protein from Homo sapiens)
- Propionyl-coa carboxylase beta chain, mitochondrial (58 kDa, Protein from Homo sapiens)
- Human propionyl-coenzyme a carboxylase heterododecomer (Complex from Homo sapiens)