DNA-directed RNA polymerase with transcriptional activator PafBC
Schilling CM, Zdanowicz R, Rabl J, Muller AU, Boehringer D, Glockshuber R, Weber-Ban E
Sci Adv (2025) 11 pp. eadq9054-eadq9054 [ DOI: doi:10.1126/sciadv.adq9054 Pubmed: 39919186 ]
- Dna-directed rna polymerase subunit alpha (Protein from Mycolicibacterium smegmatis MC2 155)
- Rna polymerase-binding protein rbpa (Protein from Mycolicibacterium smegmatis MC2 155)
- Reca-op template strand (DNA from Mycolicibacterium smegmatis MC2 155)
- Dna-directed rna polymerase subunit beta' (Protein from Mycolicibacterium smegmatis MC2 155)
- Dna-directed rna polymerase with transcriptional activator pafbc (Complex from Mycolicibacterium smegmatis MC2 155)
- Dna-directed rna polymerase subunit omega (Protein from Mycolicibacterium smegmatis MC2 155)
- Pafb (Protein from Mycolicibacterium smegmatis MC2 155)
- Rna polymerase sigma factor siga (Protein from Mycolicibacterium smegmatis MC2 155)
- Reca-op non-template strand (DNA from Mycolicibacterium smegmatis MC2 155)
- Dna-directed rna polymerase subunit beta (Protein from Mycolicibacterium smegmatis MC2 155)
- Pafc (Protein from Mycolicibacterium smegmatis MC2 155)
Transcriptional activator PafBC bound to mycobacterial RNA polymerase
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 9fnd
Q-score: 0.332
Schilling CM, Zdanowicz R, Rabl J, Muller AU, Boehringer D, Glockshuber R, Weber-Ban E
Sci Adv (2025) 11 pp. eadq9054-eadq9054 [ DOI: doi:10.1126/sciadv.adq9054 Pubmed: 39919186 ]
- Transcriptional activator pafbc bound to mycobacterial rna polymerase (Complex from Mycolicibacterium smegmatis MC2 155)
- Dna-directed rna polymerase (Complex from Mycolicibacterium smegmatis MC2 155)
- Rnap polymerase sigma factor a and rna polymerase-binding protein rbpa (Complex from Mycolicibacterium smegmatis MC2 155)
- Pafc (34 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Pafbc (Complex from Mycolicibacterium smegmatis MC2 155)
- Transcriptional regulator-like protein (36 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Composite map of the mycobacterial PafBC-bound transcription initiation complex
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 9fne
Q-score: 0.415
Schilling CM, Zdanowicz R, Rabl J, Muller AU, Boehringer D, Glockshuber R, Weber-Ban E
Sci Adv (2025) 11 pp. eadq9054-eadq9054 [ DOI: doi:10.1126/sciadv.adq9054 Pubmed: 39919186 ]
- Dna-directed rna polymerase subunit omega (11 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerase subunit beta (128 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Reca-op template strand (20 kDa, DNA from Mycolicibacterium smegmatis MC2 155)
- Transcriptional regulator-like protein (36 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Dna-directed rna polymerase with transcriptional activator pafbc (Complex from Mycolicibacterium smegmatis MC2 155)
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerase subunit beta' (146 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Rna polymerase-binding protein rbpa (13 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Pafc (34 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Rna polymerase sigma factor siga (51 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Dna-directed rna polymerase subunit alpha (37 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Reca-op non-template strand (21 kDa, DNA from Mycolicibacterium smegmatis MC2 155)
transcriptional activator PafBC bound to mycobacterial RNA polymerase
Muller AU, Kummer E, Schilling CM, Ban N, Weber-Ban E
Sci Adv (2021) 7 pp. eabl4064-eabl4064 [ DOI: doi:10.1126/sciadv.abl4064 Pubmed: 34851662 ]
- Dna-directed rna polymerase with transcriptional activator pafbc (Complex)
- Rna polymerase sigma factor siga, rna polymerase-binding protein rbpa and rna polymerase-binding transcription factor card (Complex from Mycobacterium smegmatis)
- Dna-dependent rna polymerase (Complex from Mycobacterium smegmatis)
- Pafb and pafc (Complex from Mycobacterium smegmatis)
Mycobacterial RNAP with transcriptional activator PafBC
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7p5x
Q-score: 0.532
Muller AU, Kummer E, Schilling CM, Ban N, Weber-Ban E
Sci Adv (2021) 7 pp. eabl4064-eabl4064 [ DOI: doi:10.1126/sciadv.abl4064 Pubmed: 34851662 ]
- Dna-directed rna polymerase subunit omega (11 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Transcriptional regulator-like protein (36 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Dna-directed rna polymerase subunit beta (128 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Reca-op template strand (23 kDa, DNA from Mycolicibacterium smegmatis MC2 155)
- Zinc ion (65 Da, Ligand)
- Reca-op non-template strand (23 kDa, DNA from Mycolicibacterium smegmatis MC2 155)
- Dna-directed rna polymerase subunit beta' (146 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Rna polymerase-binding protein rbpa (13 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Pafc (34 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Dna-directed rna polymerase with transcriptional activator pafbc (Complex)
- Rna polymerase sigma factor siga (51 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Dna-directed rna polymerase subunit alpha (37 kDa, Protein from Mycolicibacterium smegmatis MC2 155)