Structure of mouse RyR1 in complex with S100A1 (high-Ca2+/CFF/ATP dataset)
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8vk4
Q-score: 0.44
Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR
PNAS (2024) 121 pp. e2400497121-e2400497121 [ DOI: doi:10.1073/pnas.2400497121 Pubmed: 38917010 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Protein s100a1 (10 kDa, Protein from Mus musculus)
- Caffeine (194 Da, Ligand)
- Complex of ryr1 with calstabin-1 and s100a1 (high-ca2+/cff/atp condition) (Complex from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Mus musculus)
- Ryanodine receptor 1 (565 kDa, Protein from Mus musculus)
Structure of mouse RyR1 in complex with S100A1 (EGTA-only dataset)
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8vk3
Q-score: 0.491
Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR
PNAS (2024) 121 pp. e2400497121-e2400497121 [ DOI: doi:10.1073/pnas.2400497121 Pubmed: 38917010 ]
- Zinc ion (65 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Protein s100a1 (10 kDa, Protein from Mus musculus)
- Complex of ryr1 with calstabin-1 and s100a1 (egta condition) (Complex from Mus musculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Mus musculus)
- Ryanodine receptor 1 (565 kDa, Protein from Mus musculus)
Structure of mouse RyR1 (EGTA-only dataset)
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8vjj
Q-score: 0.597
Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR
PNAS (2024) 121 pp. e2400497121-e2400497121 [ DOI: doi:10.1073/pnas.2400497121 Pubmed: 38917010 ]
- Zinc ion (65 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Mus musculus)
- Complex of ryr1 with calstabin-1 (egta condition) (Complex from Mus musculus)
- Ryanodine receptor 1 (565 kDa, Protein from Mus musculus)
Structure of mouse RyR1 (high-Ca2+/CFF/ATP dataset)
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8vjk
Q-score: 0.533
Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR
PNAS (2024) 121 pp. e2400497121-e2400497121 [ DOI: doi:10.1073/pnas.2400497121 Pubmed: 38917010 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Complex of ryr1 with calstabin-1 (high-ca2+/cff/atp condition) (Complex from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Mus musculus)
- Ryanodine receptor 1 (565 kDa, Protein from Mus musculus)
Structure of PKA phosphorylated human RyR2-R420Q in the primed state
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8uxc
Q-score: 0.466
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Complex of ryr2-r420q and calstabin-2 (Complex)
Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8uxe
Q-score: 0.391
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl]benzoic acid (329 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r420q and calstabin-2 in the presence of arm210 (Complex)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420W in the primed state
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8uxf
Q-score: 0.454
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8uxg
Q-score: 0.434
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl]benzoic acid (329 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8uxh
Q-score: 0.366
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8uxi
Q-score: 0.39
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)