Structure of mouse RyR1 (EGTA-only dataset)
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8vjj
Q-score: 0.597
Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR
PNAS (2024) 121 pp. e2400497121-e2400497121 [ Pubmed: 38917010 DOI: doi:10.1073/pnas.2400497121 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Mus musculus)
- Zinc ion (65 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Complex of ryr1 with calstabin-1 (egta condition) (Complex from Mus musculus)
- Ryanodine receptor 1 (565 kDa, Protein from Mus musculus)
Structure of mouse RyR1 (high-Ca2+/CFF/ATP dataset)
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8vjk
Q-score: 0.533
Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR
PNAS (2024) 121 pp. e2400497121-e2400497121 [ Pubmed: 38917010 DOI: doi:10.1073/pnas.2400497121 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Mus musculus)
- Complex of ryr1 with calstabin-1 (high-ca2+/cff/atp condition) (Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
Structure of PKA phosphorylated human RyR2-R420Q in the primed state
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8uxc
Q-score: 0.466
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ DOI: doi:10.1038/s41467-024-51791-y Pubmed: 39278969 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r420q and calstabin-2 (Complex)
Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8uxe
Q-score: 0.391
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ DOI: doi:10.1038/s41467-024-51791-y Pubmed: 39278969 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r420q and calstabin-2 in the presence of arm210 (Complex)
- 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl]benzoic acid (329 Da, Ligand)
Structure of PKA phosphorylated human RyR2-R420W in the primed state
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8uxf
Q-score: 0.454
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ DOI: doi:10.1038/s41467-024-51791-y Pubmed: 39278969 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8uxg
Q-score: 0.434
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ DOI: doi:10.1038/s41467-024-51791-y Pubmed: 39278969 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl]benzoic acid (329 Da, Ligand)
Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8uxh
Q-score: 0.366
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ DOI: doi:10.1038/s41467-024-51791-y Pubmed: 39278969 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8uxi
Q-score: 0.39
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ DOI: doi:10.1038/s41467-024-51791-y Pubmed: 39278969 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8uxl
Q-score: 0.417
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ DOI: doi:10.1038/s41467-024-51791-y Pubmed: 39278969 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Calmodulin (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r420w, calstabin-2, and calmodulin (Complex)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8uxm
Q-score: 0.381
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ DOI: doi:10.1038/s41467-024-51791-y Pubmed: 39278969 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Calmodulin (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r420w, calstabin-2, and calmodulin (Complex)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)