Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Structure of human RyR2 in the closed state.
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Structure of PKA phosphorylated human RyR2 in the closed state
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7u9q
Q-score: 0.377
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Complex of ryr2 and calstabin-2 (Complex)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2 in the open state
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 7u9r
Q-score: 0.353
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Complex of ryr2 and calstabin-2 (Complex)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Xanthine (152 Da, Ligand)
Structure of PKA phosphorylated human RyR2 in the closed state in the presence of Calmodulin
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 7u9t
Q-score: 0.427
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Complex of ryr2, calstabin-2, and calmodulin (Complex)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b, calmodulin-1 (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R2474S in the closed state
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 7u9x
Q-score: 0.515
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r2474s and calstabin-2 (Complex)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R2474S in the open state
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7u9z
Q-score: 0.394
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Complex of ryr2-r2474s and calstabin-2 (Complex)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Xanthine (152 Da, Ligand)
Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of ARM210
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 7ua1
Q-score: 0.465
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl]benzoic acid (329 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r2474s and calstabin-2 in the presence of arm210 (Complex)
Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of Calmodulin
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7ua3
Q-score: 0.447
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b, calmodulin-1 (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Complex of ryr2-r2474s, calstabin-2, and calmodulin (Complex)
Structure of PKA phosphorylated human RyR2-R2474S in the open state in the presence of Calmodulin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7ua4
Q-score: 0.456
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Water (18 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (e.c.5.2.1.8), calmodulin-1 (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Complex of ryr2-r2474s, calstabin-2, and calmodulin (Complex)
- Xanthine (152 Da, Ligand)