Structure of Complement C5 in Complex with small molecule inhibitor and CVF
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8ayh
Q-score: 0.516
Jendza K, Kato M, Salcius M, Srinivas H, De Erkenez A, Nguyen A, McLaughlin D, Be C, Wiesmann C, Murphy J, Bolduc P, Mogi M, Duca J, Namil A, Capparelli M, Darsigny V, Meredith E, Tichkule R, Ferrara L, Heyder J, Liu F, Horton PA, Romanowski MJ, Schirle M, Mainolfi N, Anderson K, Michaud GA
Nat Chem Biol (2019) 15 pp. 666-668 [ DOI: doi:10.1038/s41589-019-0303-9 Pubmed: 31209353 ]
- Complement c5 alpha chain (112 kDa, Protein from Homo sapiens)
- Cobra venom factor (184 kDa, Protein from Naja kaouthia)
- 5-methoxy-2-[[(1~{s})-1-(2-methoxyphenyl)ethyl]carbamoylamino]-4-(4-methylpentoxy)benzoic acid (444 Da, Ligand)
- Complement c5-inhibitor-cvf complex (320 kDa, Complex from Homo sapiens)
- Complement c5 beta chain (73 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
Leishmania tarentolae proteasome 20S subunit in complex with compound 2
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7zyj
Q-score: 0.565
Koester DC, Marx VM, Williams S, Jiricek J, Dauphinais M, Rene O, Miller SL, Zhang L, Patra D, Chen YL, Cheung H, Gable J, Lakshminarayana SB, Osborne C, Galarneau JR, Kulkarni U, Richmond W, Bretz A, Xiao L, Supek F, Wiesmann C, Honnappa S, Be C, Maser P, Kaiser M, Ritchie R, Barrett MP, Diagana TT, Sarko C, Rao SPS
J Med Chem (2022) 65 pp. 11776-11787 [ Pubmed: 35993839 DOI: doi:10.1021/acs.jmedchem.2c00791 ]
- Proteasome alpha 1 subunit, putative (47 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (23 kDa, Protein from Leishmania tarentolae)
- Proteasome beta 6 subunit, putative (37 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- ~{n}-cyclopentyl-6-methyl-4-phenylazanyl-quinoline-2-carboxamide (345 Da, Ligand)
- Proteasome alpha 7 subunit, putative (25 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
- Proteasome (840 kDa, Complex from Leishmania tarentolae)
- Proteasome alpha 5 subunit, putative (38 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania tarentolae)
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 6sj7
Q-score: 0.46
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J
Nat Chem Biol (2020) 16 pp. 15-23 [ Pubmed: 31819272 DOI: doi:10.1038/s41589-019-0411-6 ]
- N~1~-(3-chloro-1h-indol-7-yl)benzene-1,4-disulfonamide (385 Da, Ligand)
- Ddb1 complex (210 kDa, Complex)
- Det1- and ddb1-associated protein 1 (11 kDa, Protein from Homo sapiens)
- Ddb1-dda1-dcaf15-rbm39 complex (Complex from Homo sapiens)
- Rbm39 (Complex from Homo sapiens)
- Ddb1- and cul4-associated factor 15 (66 kDa, Protein from Homo sapiens)
- Rna binding protein 39 (9 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)