Leishmania tarentolae proteasome 20S subunit in complex with compound 2
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7zyj
Q-score: 0.565
Koester DC, Marx VM, Williams S, Jiricek J, Dauphinais M, Rene O, Miller SL, Zhang L, Patra D, Chen YL, Cheung H, Gable J, Lakshminarayana SB, Osborne C, Galarneau JR, Kulkarni U, Richmond W, Bretz A, Xiao L, Supek F, Wiesmann C, Honnappa S, Be C, Maser P, Kaiser M, Ritchie R, Barrett MP, Diagana TT, Sarko C, Rao SPS
J Med Chem (2022) 65 pp. 11776-11787 [ Pubmed: 35993839 DOI: doi:10.1021/acs.jmedchem.2c00791 ]
- Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 7 subunit, putative (25 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 5 subunit, putative (38 kDa, Protein from Leishmania tarentolae)
- ~{n}-cyclopentyl-6-methyl-4-phenylazanyl-quinoline-2-carboxamide (345 Da, Ligand)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (23 kDa, Protein from Leishmania tarentolae)
- Proteasome beta 6 subunit, putative (37 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 1 subunit, putative (47 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania tarentolae)
- Proteasome (840 kDa, Complex from Leishmania tarentolae)
Leishmania tarentolae proteasome 20S subunit complexed with LXE408
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6tcz
Q-score: 0.514
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V
J Med Chem (2020) 63 pp. 10773-10781 [ Pubmed: 32667203 DOI: doi:10.1021/acs.jmedchem.0c00499 ]
- Proteasome subunit family protein (23 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (27 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania donovani)
- Leishmania tarentolae proteasome 20s subunit complex (Complex from Leishmania donovani)
- Proteasome subunit beta (30 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (33 kDa, Protein from Leishmania donovani)
- ~{n}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (443 Da, Ligand)
- Proteasome subunit alpha type (38 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (47 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (37 kDa, Protein from Leishmania donovani)
Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6td5
Q-score: 0.512
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V
J Med Chem (2020) 63 pp. 10773-10781 [ Pubmed: 32667203 DOI: doi:10.1021/acs.jmedchem.0c00499 ]
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)
- Proteasome subunit family protein (23 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania donovani)
- Leishmania tarentolae proteasome 20s subunit complexed with lxe408 and bortezomib (Complex from Leishmania donovani)
- Proteasome endopeptidase complex (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (38 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (47 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania donovani)
- ~{n}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (443 Da, Ligand)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (37 kDa, Protein from Leishmania donovani)
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 6sj7
Q-score: 0.46
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J
Nat Chem Biol (2020) 16 pp. 15-23 [ DOI: doi:10.1038/s41589-019-0411-6 Pubmed: 31819272 ]
- Rbm39 (Complex from Homo sapiens)
- Ddb1- and cul4-associated factor 15 (66 kDa, Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (11 kDa, Protein from Homo sapiens)
- Ddb1-dda1-dcaf15-rbm39 complex (Complex from Homo sapiens)
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
- Rna binding protein 39 (9 kDa, Protein from Homo sapiens)
- Ddb1 complex (210 kDa, Complex)
- N~1~-(3-chloro-1h-indol-7-yl)benzene-1,4-disulfonamide (385 Da, Ligand)