Leishmania tarentolae proteasome 20S subunit complexed with LXE408
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6tcz
Q-score: 0.514
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V
J Med Chem (2020) 63 pp. 10773-10781 [ Pubmed: 32667203 DOI: doi:10.1021/acs.jmedchem.0c00499 ]
- Proteasome subunit family protein (23 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (27 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania donovani)
- Leishmania tarentolae proteasome 20s subunit complex (Complex from Leishmania donovani)
- Proteasome subunit beta (30 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (33 kDa, Protein from Leishmania donovani)
- ~{n}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (443 Da, Ligand)
- Proteasome subunit alpha type (38 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (47 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (37 kDa, Protein from Leishmania donovani)
Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6td5
Q-score: 0.512
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V
J Med Chem (2020) 63 pp. 10773-10781 [ Pubmed: 32667203 DOI: doi:10.1021/acs.jmedchem.0c00499 ]
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)
- Proteasome subunit family protein (23 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania donovani)
- Leishmania tarentolae proteasome 20s subunit complexed with lxe408 and bortezomib (Complex from Leishmania donovani)
- Proteasome endopeptidase complex (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (38 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (47 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania donovani)
- ~{n}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (443 Da, Ligand)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (37 kDa, Protein from Leishmania donovani)
Cryo-EM structure of BK polyomavirus like particle in complex with single chain antibody ScFv41F17
Resolution: 4.24 Å
EM Method: Single-particle
Fitted PDBs: 6gg0
Q-score: 0.419
Lindner JM, Cornacchione V, Sathe A, Be C, Srinivas H, Riquet E, Leber XC, Hein A, Wrobel MB, Scharenberg M, Pietzonka T, Wiesmann C, Abend J, Traggiai E
Immunity (2019) 50 pp. 668-676.e5 [ DOI: doi:10.1016/j.immuni.2019.02.003 Pubmed: 30824324 ]
- Bk polyomavirus like particle in complex with single chain antibody scfv41f17 (13 MDa, Complex)
- Bk polyomavirus like particle (Complex from BK polyomavirus)
- Capsid protein vp1 (40 kDa, Protein from BK polyomavirus)
- Antibody scfv41f17 (Complex from Homo sapiens)
- Heavy chain (13 kDa, Protein from Homo sapiens)
- Light chain (11 kDa, Protein from Homo sapiens)