Structure of radafaxine-bound state of the human Norepinephrine Transporter
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8xb2
Q-score: 0.555
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ DOI: doi:10.1038/s41586-024-07810-5 Pubmed: 39143211 ]
- Net (Complex from Homo sapiens)
- Gfp-mbp-solute carrier family 6 member 2,maltose/maltodextrin-binding periplasmic protein,sodium-dependent noradrenaline transporter,maltose/maltodextrin-binding periplasmic protein,sodium-dependent noradrenaline transporter (138 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Radafaxine (255 Da, Ligand)
Structural mechanism of substrate binding and inhibition of the human Norepinephrine Transporter
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8xb3
Q-score: 0.592
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ DOI: doi:10.1038/s41586-024-07810-5 Pubmed: 39143211 ]
- Net (Complex from Homo sapiens)
- Gfp-mbp-solute carrier family 6 member 2 (138 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Iobenguane (275 Da, Ligand)
Structure of apo state of the human Norepinephrine Transporter
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8xb4
Q-score: 0.573
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ DOI: doi:10.1038/s41586-024-07810-5 Pubmed: 39143211 ]
- Net (Complex from Homo sapiens)
- Gfp-mbp-solute carrier family 6 member 2 (138 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of SUR2A in complex with Mg-ATP and repaglinide in the inward-facing conformation.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7y1j
Q-score: 0.58
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ Pubmed: 37330603 DOI: doi:10.1038/s41467-023-39379-4 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform a (174 MDa, Complex from Rattus norvegicus)
- Atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Repaglinide (452 Da, Ligand)
Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7y1k
Q-score: 0.413
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ Pubmed: 37330603 DOI: doi:10.1038/s41467-023-39379-4 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform a (174 MDa, Complex from Rattus norvegicus)
- Atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Repaglinide (452 Da, Ligand)
Structure of SUR2B in complex with Mg-ATP and repaglinide in the inward-facing conformation
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7y1l
Q-score: 0.424
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ Pubmed: 37330603 DOI: doi:10.1038/s41467-023-39379-4 ]
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Magnesium ion (24 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Repaglinide (452 Da, Ligand)
Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 7y1m
Q-score: 0.467
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ Pubmed: 37330603 DOI: doi:10.1038/s41467-023-39379-4 ]
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Repaglinide (452 Da, Ligand)
Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the partially occluded state
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 7y1n
Q-score: 0.466
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ Pubmed: 37330603 DOI: doi:10.1038/s41467-023-39379-4 ]
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Repaglinide (452 Da, Ligand)
Structure of human phagocyte NADPH oxidase in the resting state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gz3
Q-score: 0.559
Liu R, Song K, Wu JX, Geng XP, Zheng L, Gao X, Peng H, Chen L
eLife (2022) 11 [ DOI: doi:10.7554/eLife.83743 Pubmed: 36413210 ]
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Nadph oxidase2 (Complex)
- Cytochrome b-245 light chain (21 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- 7d5 fab heavy chain (18 kDa, Protein from Mus musculus)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cytochrome b-245 heavy chain (65 kDa, Protein from Homo sapiens)
- 7d5 fab light chain (17 kDa, Protein from Mus musculus)
- Green fluorescent protein, anti-fab (kappa) nanobody[tp1170] chimera (46 kDa, Protein from Vicugna pacos)
Consensus map of human phagocyte NADPH oxidase in the resting state
Liu R, Song K, Wu JX, Geng XP, Zheng L, Gao X, Peng H, Chen L
eLife (2022) 11 [ Pubmed: 36413210 DOI: doi:10.7554/eLife.83743 ]
- Nadph oxidase2 (Complex from Homo sapiens)
- Fab (Complex from Mus musculus)
- Nadph oxidase2 with fab and nanobody (Complex)
- Anti-fab nanobody (Complex from Vicugna pacos)