Structure of SUR1 in complex with mitiglinide
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 7wit
Q-score: 0.468
Front Pharmacol (2022) 13 pp. 929684-929684 [ Pubmed: 35847046 DOI: doi:10.3389/fphar.2022.929684 ]
- Sulfonylurea receptor 1 (Complex from Mesocricetus auratus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-4-[(3ar,7as)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic acid (315 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11,atp-binding cassette sub-family c member 8 isoform x1 (159 kDa, Protein from Mesocricetus auratus)
The structure of KATP H175K mutant in pre-open state
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 7w4o
Q-score: 0.511
Nat Commun (2022) 13 pp. 2770-2770 [ Pubmed: 35589716 DOI: doi:10.1038/s41467-022-30430-4 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 6-chloranyl-~{n}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{h}-thieno[3,2-e][1,2,4]thiadiazin-3-amine (291 Da, Ligand)
- Kir6.2 h175k mutant in complex with sur1 (Complex from Mus musculus)
- Sur1 (Complex)
- Atp-binding cassette sub-family c member 8 isoform x2 (177 kDa, Protein from Mesocricetus auratus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Mus musculus)
- Kir6.2 h175k mutant (Complex from Mesocricetus auratus)
The structure of KATP H175K mutant in closed state
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7w4p
Q-score: 0.491
Nat Commun (2022) 13 pp. 2770-2770 [ Pubmed: 35589716 DOI: doi:10.1038/s41467-022-30430-4 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 6-chloranyl-~{n}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{h}-thieno[3,2-e][1,2,4]thiadiazin-3-amine (291 Da, Ligand)
- Kir6.2 h175k mutant in complex with sur1 (Complex from Mus musculus)
- Sur1 (Complex)
- Atp-binding cassette sub-family c member 8 isoform x2 (177 kDa, Protein from Mesocricetus auratus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Mus musculus)
- Kir6.2 h175k mutant (Complex from Mesocricetus auratus)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6jb1
Q-score: 0.406
Ding D, Wang M, Wu JX, Kang Y, Chen L
Cell Rep (2019) 27 pp. 1848-1857.e4 [ Pubmed: 31067468 DOI: doi:10.1016/j.celrep.2019.04.050 ]
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Mus musculus)
- Katp (Complex from Mus musculus)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Digitonin (1 kDa, Ligand)
- Repaglinide (452 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Atp-binding cassette sub-family c member 8 isoform x2 (177 kDa, Protein from Mesocricetus auratus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of SUR1 subunit bound with repaglinide
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 6jb3
Q-score: 0.461
Ding D, Wang M, Wu JX, Kang Y, Chen L
Cell Rep (2019) 27 pp. 1848-1857.e4 [ Pubmed: 31067468 DOI: doi:10.1016/j.celrep.2019.04.050 ]
- Repaglinide (452 Da, Ligand)
- Atp-binding cassette sub-family c member 8 isoform x2 (177 kDa, Protein from Mesocricetus auratus)
- Digitonin (1 kDa, Ligand)
- Sur1 (Complex from Mus musculus)
Structure of a SUR1 fusion protein
Ding D, Wang M, Wu JX, Kang Y, Chen L
Cell Rep (2019) 27 pp. 1848-1857.e4 [ Pubmed: 31067468 DOI: doi:10.1016/j.celrep.2019.04.050 ]
- Katp (Complex from Mus musculus)
Structure of atOSCA1.1 channel
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 6jpf
Q-score: 0.409
Zhang M, Wang D, Kang Y, Wu JX, Yao F, Pan C, Yan Z, Song C, Chen L
Nat Struct Mol Biol (2018) 25 pp. 850-858 [ DOI: doi:10.1038/s41594-018-0117-6 Pubmed: 30190597 ]
- Protein osca1 (87 kDa, Protein from Arabidopsis thaliana)
- Atosca1.1 (175 kDa, Complex from Arabidopsis thaliana)
Structure of atOSCA3.1 channel
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 5z1f
Q-score: 0.273
Zhang M, Wang D, Kang Y, Wu JX, Yao F, Pan C, Yan Z, Song C, Chen L
Nat Struct Mol Biol (2018) 25 pp. 850-858 [ DOI: doi:10.1038/s41594-018-0117-6 Pubmed: 30190597 ]
- Csc1-like protein erd4 (82 kDa, Protein from Arabidopsis thaliana)
- Atosca3.1 (175 kDa, Complex from Arabidopsis thaliana)
Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class2 at 5.2A)
Resolution: 5.2 Å
EM Method: Single-particle
Fitted PDBs: 5ywb
Q-score: 0.193
Wu JX, Ding D, Wang M, Kang Y, Zeng X, Chen L
Protein Cell (2018) 9 pp. 553-567 [ DOI: doi:10.1007/s13238-018-0530-y Pubmed: 29594720 ]
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Mus musculus)
- Katp (Complex from Mus musculus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family c member 8 isoform x2 (177 kDa, Protein from Mesocricetus auratus)
- Magnesium ion (24 Da, Ligand)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 5yw7
Q-score: 0.305
Wu JX, Ding D, Wang M, Kang Y, Zeng X, Chen L
Protein Cell (2018) 9 pp. 553-567 [ DOI: doi:10.1007/s13238-018-0530-y Pubmed: 29594720 ]
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Atp-binding cassette sub-family c member 8 isoform x2 (177 kDa, Protein from Mesocricetus auratus)
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Katp (Complex from Mesocricetus auratus)