Structure of radafaxine-bound state of the human Norepinephrine Transporter
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8xb2
Q-score: 0.555
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ Pubmed: 39143211 DOI: doi:10.1038/s41586-024-07810-5 ]
- Radafaxine (255 Da, Ligand)
- Gfp-mbp-solute carrier family 6 member 2,maltose/maltodextrin-binding periplasmic protein,sodium-dependent noradrenaline transporter,maltose/maltodextrin-binding periplasmic protein,sodium-dependent noradrenaline transporter (138 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Net (Complex from Homo sapiens)
Structural mechanism of substrate binding and inhibition of the human Norepinephrine Transporter
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8xb3
Q-score: 0.592
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ Pubmed: 39143211 DOI: doi:10.1038/s41586-024-07810-5 ]
- Gfp-mbp-solute carrier family 6 member 2 (138 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Iobenguane (275 Da, Ligand)
- Net (Complex from Homo sapiens)
Structure of apo state of the human Norepinephrine Transporter
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8xb4
Q-score: 0.573
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ Pubmed: 39143211 DOI: doi:10.1038/s41586-024-07810-5 ]
- Gfp-mbp-solute carrier family 6 member 2 (138 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Net (Complex from Homo sapiens)
Structure of human phagocyte NADPH oxidase in the resting state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gz3
Q-score: 0.559
Liu R, Song K, Wu JX, Geng XP, Zheng L, Gao X, Peng H, Chen L
eLife (2022) 11 [ Pubmed: 36413210 DOI: doi:10.7554/eLife.83743 ]
- 7d5 fab light chain (17 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Nadph oxidase2 (Complex)
- Green fluorescent protein, anti-fab (kappa) nanobody[tp1170] chimera (46 kDa, Protein from Vicugna pacos)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- 7d5 fab heavy chain (18 kDa, Protein from Mus musculus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Cytochrome b-245 light chain (21 kDa, Protein from Homo sapiens)
- Cytochrome b-245 heavy chain (65 kDa, Protein from Homo sapiens)
- Flavin-adenine dinucleotide (785 Da, Ligand)
Consensus map of human phagocyte NADPH oxidase in the resting state
Liu R, Song K, Wu JX, Geng XP, Zheng L, Gao X, Peng H, Chen L
eLife (2022) 11 [ Pubmed: 36413210 DOI: doi:10.7554/eLife.83743 ]
- Anti-fab nanobody (Complex from Vicugna pacos)
- Nadph oxidase2 with fab and nanobody (Complex)
- Nadph oxidase2 (Complex from Homo sapiens)
- Fab (Complex from Mus musculus)
Liu R, Song K, Wu JX, Geng XP, Zheng L, Gao X, Peng H, Chen L
eLife (2022) 11 [ Pubmed: 36413210 DOI: doi:10.7554/eLife.83743 ]
- Nadph oxidase2 (Complex from Homo sapiens)
Focus refined map of human phagocyte NADPH oxidase core in the resting state
Liu R, Song K, Wu JX, Geng XP, Zheng L, Gao X, Peng H, Chen L
eLife (2022) 11 [ Pubmed: 36413210 DOI: doi:10.7554/eLife.83743 ]
- Nadph oxidase2 (Complex from Homo sapiens)
Focus refined map of the DH domain of human phagocyte NADPH oxidase in the resting state
Liu R, Song K, Wu JX, Geng XP, Zheng L, Gao X, Peng H, Chen L
eLife (2022) 11 [ Pubmed: 36413210 DOI: doi:10.7554/eLife.83743 ]
- Nadph oxidase2 (Complex from Homo sapiens)
Structure of human TRPC5 in complex with clemizole
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7d4p
Q-score: 0.563
Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
eLife (2021) 10 [ Pubmed: 33683200 DOI: doi:10.7554/eLife.63429 ]
- Zinc ion (65 Da, Ligand)
- Human transient receptor potential channel 5 tetramer (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole (325 Da, Ligand)
- Short transient receptor potential channel 5 (88 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of human TRPC5 in complex with HC-070
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 7d4q
Q-score: 0.581
Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
eLife (2021) 10 [ Pubmed: 33683200 DOI: doi:10.7554/eLife.63429 ]
- Zinc ion (65 Da, Ligand)
- Human transient receptor potential channel 5 tetramer (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione (475 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Short transient receptor potential channel 5 (88 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)