Structure of radafaxine-bound state of the human Norepinephrine Transporter
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8xb2
Q-score: 0.555
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ Pubmed: 39143211 DOI: doi:10.1038/s41586-024-07810-5 ]
- Radafaxine (255 Da, Ligand)
- Gfp-mbp-solute carrier family 6 member 2,maltose/maltodextrin-binding periplasmic protein,sodium-dependent noradrenaline transporter,maltose/maltodextrin-binding periplasmic protein,sodium-dependent noradrenaline transporter (138 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Net (Complex from Homo sapiens)
Structural mechanism of substrate binding and inhibition of the human Norepinephrine Transporter
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8xb3
Q-score: 0.592
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ Pubmed: 39143211 DOI: doi:10.1038/s41586-024-07810-5 ]
- Gfp-mbp-solute carrier family 6 member 2 (138 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Iobenguane (275 Da, Ligand)
- Net (Complex from Homo sapiens)
Structure of apo state of the human Norepinephrine Transporter
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8xb4
Q-score: 0.573
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ Pubmed: 39143211 DOI: doi:10.1038/s41586-024-07810-5 ]
- Gfp-mbp-solute carrier family 6 member 2 (138 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Net (Complex from Homo sapiens)
Structure of SUR2A in complex with Mg-ATP and repaglinide in the inward-facing conformation.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7y1j
Q-score: 0.58
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ Pubmed: 37330603 DOI: doi:10.1038/s41467-023-39379-4 ]
- Repaglinide (452 Da, Ligand)
- Atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform a (174 MDa, Complex from Rattus norvegicus)
Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7y1k
Q-score: 0.413
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ Pubmed: 37330603 DOI: doi:10.1038/s41467-023-39379-4 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Repaglinide (452 Da, Ligand)
- Atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform a (174 MDa, Complex from Rattus norvegicus)
Structure of SUR2B in complex with Mg-ATP and repaglinide in the inward-facing conformation
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7y1l
Q-score: 0.424
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ Pubmed: 37330603 DOI: doi:10.1038/s41467-023-39379-4 ]
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
- Repaglinide (452 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 7y1m
Q-score: 0.467
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ Pubmed: 37330603 DOI: doi:10.1038/s41467-023-39379-4 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
- Repaglinide (452 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the partially occluded state
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 7y1n
Q-score: 0.466
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ Pubmed: 37330603 DOI: doi:10.1038/s41467-023-39379-4 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
- Repaglinide (452 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
Structure of human phagocyte NADPH oxidase in the resting state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gz3
Q-score: 0.559
Liu R, Song K, Wu JX, Geng XP, Zheng L, Gao X, Peng H, Chen L
eLife (2022) 11 [ Pubmed: 36413210 DOI: doi:10.7554/eLife.83743 ]
- 7d5 fab light chain (17 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Nadph oxidase2 (Complex)
- Green fluorescent protein, anti-fab (kappa) nanobody[tp1170] chimera (46 kDa, Protein from Vicugna pacos)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- 7d5 fab heavy chain (18 kDa, Protein from Mus musculus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Cytochrome b-245 light chain (21 kDa, Protein from Homo sapiens)
- Cytochrome b-245 heavy chain (65 kDa, Protein from Homo sapiens)
- Flavin-adenine dinucleotide (785 Da, Ligand)
Consensus map of human phagocyte NADPH oxidase in the resting state
Liu R, Song K, Wu JX, Geng XP, Zheng L, Gao X, Peng H, Chen L
eLife (2022) 11 [ Pubmed: 36413210 DOI: doi:10.7554/eLife.83743 ]
- Anti-fab nanobody (Complex from Vicugna pacos)
- Nadph oxidase2 with fab and nanobody (Complex)
- Nadph oxidase2 (Complex from Homo sapiens)
- Fab (Complex from Mus musculus)