Structure of radafaxine-bound state of the human Norepinephrine Transporter
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8xb2
Q-score: 0.555
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ DOI: doi:10.1038/s41586-024-07810-5 Pubmed: 39143211 ]
- Radafaxine (255 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Net (Complex from Homo sapiens)
- Gfp-mbp-solute carrier family 6 member 2,maltose/maltodextrin-binding periplasmic protein,sodium-dependent noradrenaline transporter,maltose/maltodextrin-binding periplasmic protein,sodium-dependent noradrenaline transporter (138 kDa, Protein from Homo sapiens)
Structural mechanism of substrate binding and inhibition of the human Norepinephrine Transporter
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8xb3
Q-score: 0.592
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ DOI: doi:10.1038/s41586-024-07810-5 Pubmed: 39143211 ]
- Iobenguane (275 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Net (Complex from Homo sapiens)
- Gfp-mbp-solute carrier family 6 member 2 (138 kDa, Protein from Homo sapiens)
Structure of apo state of the human Norepinephrine Transporter
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8xb4
Q-score: 0.573
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ DOI: doi:10.1038/s41586-024-07810-5 Pubmed: 39143211 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Net (Complex from Homo sapiens)
- Gfp-mbp-solute carrier family 6 member 2 (138 kDa, Protein from Homo sapiens)
Structure of SUR2B in complex with Mg-ATP/ADP
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7vlr
Q-score: 0.468
Ding D, Wu JX, Duan X, Ma S, Lai L, Chen L
Nat Commun (2022) 13 pp. 2675-2675 [ DOI: doi:10.1038/s41467-022-30428-y Pubmed: 35562524 ]
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
Structure of SUR2B in complex with MgATP/ADP and P1075
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vls
Q-score: 0.494
Ding D, Wu JX, Duan X, Ma S, Lai L, Chen L
Nat Commun (2022) 13 pp. 2675-2675 [ DOI: doi:10.1038/s41467-022-30428-y Pubmed: 35562524 ]
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
- 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine (231 Da, Ligand)
Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7vlt
Q-score: 0.52
Ding D, Wu JX, Duan X, Ma S, Lai L, Chen L
Nat Commun (2022) 13 pp. 2675-2675 [ DOI: doi:10.1038/s41467-022-30428-y Pubmed: 35562524 ]
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (3s,4r)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile (286 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Structure of SUR2A in complex with Mg-ATP/ADP and P1075
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vlu
Q-score: 0.487
Ding D, Wu JX, Duan X, Ma S, Lai L, Chen L
Nat Commun (2022) 13 pp. 2675-2675 [ DOI: doi:10.1038/s41467-022-30428-y Pubmed: 35562524 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Atp-binding cassette sub-family c member 9, isoform a (174 MDa, Complex from Rattus norvegicus)
- 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine (231 Da, Ligand)