Structure of radafaxine-bound state of the human Norepinephrine Transporter
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8xb2
Q-score: 0.555
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ DOI: doi:10.1038/s41586-024-07810-5 Pubmed: 39143211 ]
- Radafaxine (255 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Net (Complex from Homo sapiens)
- Gfp-mbp-solute carrier family 6 member 2,maltose/maltodextrin-binding periplasmic protein,sodium-dependent noradrenaline transporter,maltose/maltodextrin-binding periplasmic protein,sodium-dependent noradrenaline transporter (138 kDa, Protein from Homo sapiens)
Structural mechanism of substrate binding and inhibition of the human Norepinephrine Transporter
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8xb3
Q-score: 0.592
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ DOI: doi:10.1038/s41586-024-07810-5 Pubmed: 39143211 ]
- Iobenguane (275 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Net (Complex from Homo sapiens)
- Gfp-mbp-solute carrier family 6 member 2 (138 kDa, Protein from Homo sapiens)
Structure of apo state of the human Norepinephrine Transporter
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8xb4
Q-score: 0.573
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024) 633 pp. 473-479 [ DOI: doi:10.1038/s41586-024-07810-5 Pubmed: 39143211 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Net (Complex from Homo sapiens)
- Gfp-mbp-solute carrier family 6 member 2 (138 kDa, Protein from Homo sapiens)
Structure of SUR2A in complex with Mg-ATP and repaglinide in the inward-facing conformation.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7y1j
Q-score: 0.58
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ DOI: doi:10.1038/s41467-023-39379-4 Pubmed: 37330603 ]
- Repaglinide (452 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Atp-binding cassette sub-family c member 9, isoform a (174 MDa, Complex from Rattus norvegicus)
Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7y1k
Q-score: 0.413
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ DOI: doi:10.1038/s41467-023-39379-4 Pubmed: 37330603 ]
- Repaglinide (452 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Atp-binding cassette sub-family c member 9, isoform a (174 MDa, Complex from Rattus norvegicus)
Structure of SUR2B in complex with Mg-ATP and repaglinide in the inward-facing conformation
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7y1l
Q-score: 0.424
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ DOI: doi:10.1038/s41467-023-39379-4 Pubmed: 37330603 ]
- Repaglinide (452 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 7y1m
Q-score: 0.467
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ DOI: doi:10.1038/s41467-023-39379-4 Pubmed: 37330603 ]
- Repaglinide (452 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the partially occluded state
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 7y1n
Q-score: 0.466
Ding D, Hou T, Wei M, Wu JX, Chen L
Nat Commun (2023) 14 pp. 3608-3608 [ DOI: doi:10.1038/s41467-023-39379-4 Pubmed: 37330603 ]
- Repaglinide (452 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
Structure of human phagocyte NADPH oxidase in the resting state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gz3
Q-score: 0.559
Liu R, Song K, Wu JX, Geng XP, Zheng L, Gao X, Peng H, Chen L
eLife (2022) 11 [ DOI: doi:10.7554/eLife.83743 Pubmed: 36413210 ]
- Water (18 Da, Ligand)
- 7d5 fab light chain (17 kDa, Protein from Mus musculus)
- Cytochrome b-245 light chain (21 kDa, Protein from Homo sapiens)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- 7d5 fab heavy chain (18 kDa, Protein from Mus musculus)
- Cytochrome b-245 heavy chain (65 kDa, Protein from Homo sapiens)
- Green fluorescent protein, anti-fab (kappa) nanobody[tp1170] chimera (46 kDa, Protein from Vicugna pacos)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nadph oxidase2 (Complex)
Consensus map of human phagocyte NADPH oxidase in the resting state
Liu R, Song K, Wu JX, Geng XP, Zheng L, Gao X, Peng H, Chen L
eLife (2022) 11 [ DOI: doi:10.7554/eLife.83743 Pubmed: 36413210 ]
- Nadph oxidase2 with fab and nanobody (Complex)
- Anti-fab nanobody (Complex from Vicugna pacos)
- Fab (Complex from Mus musculus)
- Nadph oxidase2 (Complex from Homo sapiens)