Prefusion RSV F Bound to Lonafarnib and D25 Fab
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8kg5
Q-score: 0.499
Yang Q, Xue B, Liu F, Lu Y, Tang J, Yan M, Wu Q, Chen R, Zhou A, Liu L, Liu J, Qu C, Wu Q, Fu M, Zhong J, Dong J, Chen S, Wang F, Zhou Y, Zheng J, Peng W, Shang J, Chen X
Signal Transduct Target Ther (2024) 9 pp. 144-144 [ DOI: doi:10.1038/s41392-024-01858-5 Pubmed: 38853183 ]
- D25 light chain (23 kDa, Protein from Homo sapiens)
- Fusion glycoprotein f0,fibritin (64 kDa, Protein from Enterobacteria phage T4)
- 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5h-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide (638 Da, Ligand)
- Prefusion rsv f bound to lonafarnib and d25 fab (Complex from Human respiratory syncytial virus A (strain A2))
- D25 heavy chain (24 kDa, Protein from Homo sapiens)
Voltage-gated sodium channel Nav1.7 variant M9
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8xmm
Q-score: 0.544
Li Z, Wu Q, Huang G, Jin X, Li J, Pan X, Yan N
PNAS (2024) 121 pp. e2322899121-e2322899121 [ DOI: doi:10.1073/pnas.2322899121 Pubmed: 38381792 ]
- Sodium channel subunit beta-1 (26 kDa, Protein from Homo sapiens)
- (2s,3r,4e)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (421 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-gated sodium channel nav1.7-m9 (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
Voltage-gated sodium channel Nav1.7 variant M2
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8xmn
Q-score: 0.431
Li Z, Wu Q, Huang G, Jin X, Li J, Pan X, Yan N
PNAS (2024) 121 pp. e2322899121-e2322899121 [ DOI: doi:10.1073/pnas.2322899121 Pubmed: 38381792 ]
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-1 (26 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Sodium channel subunit beta-2 (25 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Voltage-gated sodium channel nav1.7-m2 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Voltage-gated sodium channel Nav1.7 variant M4
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8xmo
Q-score: 0.455
Li Z, Wu Q, Huang G, Jin X, Li J, Pan X, Yan N
PNAS (2024) 121 pp. e2322899121-e2322899121 [ DOI: doi:10.1073/pnas.2322899121 Pubmed: 38381792 ]
- Sodium channel subunit beta-1 (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-2 (25 kDa, Protein from Homo sapiens)
- Voltage-gated sodium channel nav1.7-m4 (Complex from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
Cryo-EM structure of EBV gHgL-gp42 in complex with mAbs 3E8 and 5E3 (localized refinement)
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 7yoy
Q-score: 0.464
Hong J, Zhong L, Liu L, Wu Q, Zhang W, Chen K, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M, Zheng Q, Chen Y, Zhang X, Xia N
Cell Rep Med (2023) 4 pp. 101296-101296 [ DOI: doi:10.1016/j.xcrm.2023.101296 Pubmed: 37992686 ]
- 3e8 heavy chain (12 kDa, Protein from Oryctolagus cuniculus)
- Ebv ghgl-gp42 in complex with mabs 3e8 and 5e3 (Complex)
- Soluble gp42 (15 kDa, Protein from Human gammaherpesvirus 4)
- 5e3 heavy chain (13 kDa, Protein from Oryctolagus cuniculus)
- 5e3 light chain (11 kDa, Protein from Oryctolagus cuniculus)
- 3e8 light chain (11 kDa, Protein from Oryctolagus cuniculus)
- 5e3,3e8 (Complex from Oryctolagus cuniculus)
- Gp42 (Complex from Human gammaherpesvirus 4)
Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 10E4 (localized refinement)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7yp1
Q-score: 0.523
Hong J, Zhong L, Liu L, Wu Q, Zhang W, Chen K, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M, Zheng Q, Chen Y, Zhang X, Xia N
Cell Rep Med (2023) 4 pp. 101296-101296 [ DOI: doi:10.1016/j.xcrm.2023.101296 Pubmed: 37992686 ]
- Ebv gl (8 kDa, Protein from Human gammaherpesvirus 4)
- Ebv gh (22 kDa, Protein from Human gammaherpesvirus 4)
- 10e4 (Complex from Oryctolagus cuniculus)
- Ghgl-gp42 in complex with mab 10e4 (Complex)
- 10e4 light chain (11 kDa, Protein from Oryctolagus cuniculus)
- Gh,gl (Complex from Human gammaherpesvirus 4)
- 10e4 heavy chain (12 kDa, Protein from Oryctolagus cuniculus)
Cryo-EM density map of EBV gHgL-gp42 in complex with four mAbs 5E3, 3E8, 6H2 and 10E4
Hong J, Zhong L, Liu L, Wu Q, Zhang W, Chen K, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M, Zheng Q, Chen Y, Zhang X, Xia N
Cell Rep Med (2023) 4 pp. 101296-101296 [ DOI: doi:10.1016/j.xcrm.2023.101296 Pubmed: 37992686 ]
Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 6H2 (localized refinement)
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 7yp2
Q-score: 0.53
Hong J, Zhong L, Liu L, Wu Q, Zhang W, Chen K, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M, Zheng Q, Chen Y, Zhang X, Xia N
Cell Rep Med (2023) 4 pp. 101296-101296 [ DOI: doi:10.1016/j.xcrm.2023.101296 Pubmed: 37992686 ]
- Ebv ghgl-gp42 in complex with mab 6h2 (Complex)
- 6h2 heavy chain (13 kDa, Protein from Mus musculus)
- 6h2 (Complex from Mus musculus)
- Envelope glycoprotein h (34 kDa, Protein from Human gammaherpesvirus 4)
- Gh (Complex from Human gammaherpesvirus 4)
- 6h2 light chain (12 kDa, Protein from Mus musculus)
Cryo-EM structure of Nav1.7 with LCM
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8s9b
Q-score: 0.513
Wu Q, Huang J, Fan X, Wang K, Jin X, Huang G, Li J, Pan X, Yan N
Nat Commun (2023) 14 pp. 3224-3224 [ Pubmed: 37270609 DOI: doi:10.1038/s41467-023-38942-3 ]
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Water (18 Da, Ligand)
- Lacosamide (250 Da, Ligand)
- Human voltage-gated sodium channel nav1.7 with beta subunits (Complex from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (226 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
Cryo-EM structure of Nav1.7 with CBZ
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8s9c
Q-score: 0.5
Wu Q, Huang J, Fan X, Wang K, Jin X, Huang G, Li J, Pan X, Yan N
Nat Commun (2023) 14 pp. 3224-3224 [ Pubmed: 37270609 DOI: doi:10.1038/s41467-023-38942-3 ]
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Water (18 Da, Ligand)
- Human voltage-gated sodium channel nav1.7 with beta subunits (Complex from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (226 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Benzo[b][1]benzazepine-11-carboxamide (236 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)