Prefusion RSV F Bound to Lonafarnib and D25 Fab
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8kg5
Q-score: 0.499
Yang Q, Xue B, Liu F, Lu Y, Tang J, Yan M, Wu Q, Chen R, Zhou A, Liu L, Liu J, Qu C, Wu Q, Fu M, Zhong J, Dong J, Chen S, Wang F, Zhou Y, Zheng J, Peng W, Shang J, Chen X
Signal Transduct Target Ther (2024) 9 pp. 144-144 [ Pubmed: 38853183 DOI: doi:10.1038/s41392-024-01858-5 ]
- Fusion glycoprotein f0,fibritin (64 kDa, Protein from Enterobacteria phage T4)
- Prefusion rsv f bound to lonafarnib and d25 fab (Complex from Human respiratory syncytial virus A (strain A2))
- D25 light chain (23 kDa, Protein from Homo sapiens)
- D25 heavy chain (24 kDa, Protein from Homo sapiens)
- 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5h-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide (638 Da, Ligand)
Cryo-EM maps of the (TGA3)2-(NPR1)2-(TGA3)2 complex
Kumar S, Zavaliev R, Wu Q, Zhou Y, Cheng J, Dillard L, Powers J, Withers J, Zhao J, Guan Z, Borgnia MJ, Bartesaghi A, Dong X, Zhou P
Nature (2022) 605 pp. 561-566 [ Pubmed: 35545668 DOI: doi:10.1038/s41586-022-04699-w ]
cryo-EM maps of the (NPR1)2-(TGA3)2 complex
Kumar S, Zavaliev R, Wu Q, Zhou Y, Cheng J, Dillard L, Powers J, Withers J, Zhao J, Guan Z, Borgnia MJ, Bartesaghi A, Dong X, Zhou P
Nature (2022) 605 pp. 561-566 [ Pubmed: 35545668 DOI: doi:10.1038/s41586-022-04699-w ]
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7mk2
Q-score: 0.453
Kumar S, Zavaliev R, Wu Q, Zhou Y, Cheng J, Dillard L, Powers J, Withers J, Zhao J, Guan Z, Borgnia MJ, Bartesaghi A, Dong X, Zhou P
Nature (2022) 605 pp. 561-566 [ Pubmed: 35545668 DOI: doi:10.1038/s41586-022-04699-w ]
- Npr1 dimer (Complex from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
- Regulatory protein npr1 (67 kDa, Protein from Arabidopsis thaliana)
CryoEM Map of the NPR1-SA complex
Kumar S, Zavaliev R, Wu Q, Zhou Y, Cheng J, Dillard L, Powers J, Withers J, Zhao J, Guan Z, Borgnia MJ, Bartesaghi A, Dong X, Zhou P
Nature (2022) 605 pp. 561-566 [ Pubmed: 35545668 DOI: doi:10.1038/s41586-022-04699-w ]
Cryo-EM structure of the (TGA3)2-(NPR1)2-(TGA3)2 complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7tac
Q-score: 0.329
Kumar S, Zavaliev R, Wu Q, Zhou Y, Cheng J, Dillard L, Powers J, Withers J, Zhao J, Guan Z, Borgnia MJ, Bartesaghi A, Dong X, Zhou P
Nature (2022) 605 pp. 561-566 [ Pubmed: 35545668 DOI: doi:10.1038/s41586-022-04699-w ]
- (tga3)2-(npr1)2-(tga3)2 complex (Complex from Arabidopsis thaliana)
- Palmitic acid (256 Da, Ligand)
- Regulatory protein npr1 (67 kDa, Protein from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
- Transcription factor tga3 (36 kDa, Protein from Arabidopsis thaliana)
CryoEM structure of the (NPR1)2-(TGA3)2 complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7tad
Q-score: 0.357
Kumar S, Zavaliev R, Wu Q, Zhou Y, Cheng J, Dillard L, Powers J, Withers J, Zhao J, Guan Z, Borgnia MJ, Bartesaghi A, Dong X, Zhou P
Nature (2022) 605 pp. 561-566 [ Pubmed: 35545668 DOI: doi:10.1038/s41586-022-04699-w ]
- Palmitic acid (256 Da, Ligand)
- Regulatory protein npr1 (67 kDa, Protein from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
- (npr1)2-(tga3)2 complex (Complex from Arabidopsis thaliana)
- Transcription factor tga3 (36 kDa, Protein from Arabidopsis thaliana)