Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7mk2
Q-score: 0.453
Kumar S, Zavaliev R, Wu Q, Zhou Y, Cheng J, Dillard L, Powers J, Withers J, Zhao J, Guan Z, Borgnia MJ, Bartesaghi A, Dong X, Zhou P
Nature (2022) 605 pp. 561-566 [ Pubmed: 35545668 DOI: doi:10.1038/s41586-022-04699-w ]
- Npr1 dimer (Complex from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
- Regulatory protein npr1 (67 kDa, Protein from Arabidopsis thaliana)
Cryo-EM structure of the (TGA3)2-(NPR1)2-(TGA3)2 complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7tac
Q-score: 0.329
Kumar S, Zavaliev R, Wu Q, Zhou Y, Cheng J, Dillard L, Powers J, Withers J, Zhao J, Guan Z, Borgnia MJ, Bartesaghi A, Dong X, Zhou P
Nature (2022) 605 pp. 561-566 [ Pubmed: 35545668 DOI: doi:10.1038/s41586-022-04699-w ]
- (tga3)2-(npr1)2-(tga3)2 complex (Complex from Arabidopsis thaliana)
- Palmitic acid (256 Da, Ligand)
- Regulatory protein npr1 (67 kDa, Protein from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
- Transcription factor tga3 (36 kDa, Protein from Arabidopsis thaliana)
CryoEM structure of the (NPR1)2-(TGA3)2 complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7tad
Q-score: 0.357
Kumar S, Zavaliev R, Wu Q, Zhou Y, Cheng J, Dillard L, Powers J, Withers J, Zhao J, Guan Z, Borgnia MJ, Bartesaghi A, Dong X, Zhou P
Nature (2022) 605 pp. 561-566 [ Pubmed: 35545668 DOI: doi:10.1038/s41586-022-04699-w ]
- Palmitic acid (256 Da, Ligand)
- Regulatory protein npr1 (67 kDa, Protein from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
- (npr1)2-(tga3)2 complex (Complex from Arabidopsis thaliana)
- Transcription factor tga3 (36 kDa, Protein from Arabidopsis thaliana)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6kzo
Q-score: 0.508
Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, Pan X, Yan N
Nature (2019) 576 pp. 492-497 [ Pubmed: 31766050 DOI: doi:10.1038/s41586-019-1801-3 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Membrane protein (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1g (250 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6kzp
Q-score: 0.548
Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, Pan X, Yan N
Nature (2019) 576 pp. 492-497 [ Pubmed: 31766050 DOI: doi:10.1038/s41586-019-1801-3 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1g,voltage-dependent t-type calcium channel subunit alpha-1g (238 kDa, Protein from Homo sapiens)
- ~{n}-[[1-[2-(~{tert}-butylamino)-2-oxidanylidene-ethyl]piperidin-4-yl]methyl]-3-chloranyl-5-fluoranyl-benzamide (383 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Membrane protein-ligand (Complex from Homo sapiens)
Rabbit Cav1.1-Nifedipine Complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6jp5
Q-score: 0.39
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N
Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]
- Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
- Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Ethanolamine (61 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
- Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (346 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cav1.1-drug complex (Complex)
Rabbit Cav1.1-Bay K8644 Complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6jp8
Q-score: 0.385
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N
Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]
- Methyl (4~{s})-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate (356 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (118 kDa, Protein from Oryctolagus cuniculus)
- Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- Ethanolamine (61 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cav1.1-drug complex (Complex)
Rabbit Cav1.1-Verapamil Complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6jpa
Q-score: 0.4
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N
Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]
- Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (118 kDa, Protein from Oryctolagus cuniculus)
- Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Ethanolamine (61 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1s (172 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit beta-1 (57 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cav1.1-drug complex (Complex)
- (2s)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile (454 Da, Ligand)
Rabbit Cav1.1-Diltiazem Complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6jpb
Q-score: 0.397
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N
Cell (2019) 177 pp. 1495-1506.e12 [ DOI: doi:10.1016/j.cell.2019.04.043 Pubmed: 31150622 ]
- Voltage-dependent l-type calcium channel subunit beta-1 (49 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (118 kDa, Protein from Oryctolagus cuniculus)
- Cav1.1-beta1a-alpha2-delta1-gamma complex (Complex from Oryctolagus cuniculus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Diltiazem (414 Da, Ligand)
- Ethanolamine (61 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent l-type calcium channel subunit beta-1 (57 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cav1.1-drug complex (Complex)