Cryo-EM structure of NRG1A(LRR) in complex with EDS1-SAG101-(ADPr-ATP)
Huang S, Wang J, Song R, Jia A, Xiao Y, Sun Y, Wang L, Mahr D, Wu Z, Han Z, Li X, Parker JE, Chai J
Nature (2025) [ DOI: doi:10.1038/s41586-024-08521-7 ]
- Probable disease resistance protein at5g66900 (46 kDa, Protein from Arabidopsis thaliana)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Protein eds1 (70 kDa, Protein from Arabidopsis thaliana)
- Ternary complex of nrg1a(lrr) with eds1-sag101-(adpr-atp) (Complex from Arabidopsis)
- Senescence-associated carboxylesterase 101 (61 kDa, Protein from Arabidopsis thaliana)
- Adenosine-5'-triphosphate (507 Da, Ligand)
The Cryo-EM structure of DSR2-Tail tube-NAD+ complex
Wang R, Xu Q, Wu Z, Li J, Guo H, Liao T, Shi Y, Yuan L, Gao H, Yang R, Shi Z, Li F
Nat Commun (2024) 15 pp. 6185-6185 [ DOI: doi:10.1038/s41467-024-50410-0 Pubmed: 39039073 ]
- Tail tube protein (29 kDa, Protein from Bacillus subtilis)
- Dsr2-tail tube protein-nad+ complex (Complex from Bacillus subtilis)
- Sir2-like domain-containing protein (118 kDa, Protein from Bacillus subtilis)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8gk7
Q-score: 0.364
Wang H, Ishchenko A, Skudlarek J, Shen P, Dzhekieva L, Painter RE, Chen YT, Bukhtiyarova M, Leithead A, Tracy R, Babaoglu K, Bahnck-Teets C, Buevich A, Cabalu TD, Labroli M, Lange H, Lei Y, Li W, Liu J, Mann PA, Meng T, Mitchell HJ, Mulhearn J, Scapin G, Sha D, Shaw AW, Si Q, Tong L, Wu C, Wu Z, Xiao JC, Xu M, Zhang LK, McKenney D, Miller RR, Black TA, Cooke A, Balibar CJ, Klein DJ, Raheem I, Walker SS
Nat Microbiol (2024) 9 pp. 1244-1255 [ Pubmed: 38649414 DOI: doi:10.1038/s41564-024-01667-0 ]
- Lipid a export atp-binding/permease protein msba (66 kDa, Protein from Acinetobacter baumannii)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Msba complexed with cerastecin c (450 kDa, Complex from Acinetobacter baumannii)
- 2-[(4-butylbenzene-1-sulfonyl)amino]-5-[(3-{4-[(4-butylbenzene-1-sulfonyl)amino]-3-carboxyanilino}-3-oxopropyl)carbamoyl]benzoic acid (778 Da, Ligand)
Cryo-EM structure of the ISFba1 TnpB-reRNA-dsDNA complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8iaz
Q-score: 0.548
Ren K, Zhou F, Zhang F, Yin M, Zhu Y, Wang S, Chen Y, Huang T, Wu Z, He J, Zhang A, Guo C, Huang Z
Cell Res (2024) 34 pp. 370-385 [ DOI: doi:10.1038/s41422-024-00952-1 Pubmed: 38575718 ]
- Rna (207-mer) (66 kDa, RNA from Firmicutes bacterium AM43-11BH)
- Transposase (44 kDa, Protein from Firmicutes bacterium AM43-11BH)
- Dna (5'-d(p*cp*cp*ap*tp*tp*ap*gp*gp*ap*gp*cp*tp*gp*ap*tp*g)-3') (4 kDa, DNA from Firmicutes bacterium AM43-11BH)
- The complex of protein with grna and target dna (Complex from Firmicutes bacterium AM43-11BH)
- Dna (5'-d(p*ap*cp*ap*tp*gp*gp*ap*cp*cp*ap*tp*cp*ap*gp*cp*tp*cp*cp*tp*ap*ap*tp*gp*g)-3') (7 kDa, DNA from Firmicutes bacterium AM43-11BH)
- Zinc ion (65 Da, Ligand)
OEA bound GPR3-Gs complex structure
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8x2k
Q-score: 0.532
Chen G, Staffen N, Wu Z, Xu X, Pan J, Inoue A, Shi T, Gmeiner P, Du Y, Xu J
Cell Res (2024) 34 pp. 262-265 [ Pubmed: 38287118 DOI: doi:10.1038/s41422-023-00919-8 ]
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpr3 (Complex from Homo sapiens)
- Soluble cytochrome b562,g-protein coupled receptor 3 (50 kDa, Protein from Homo sapiens)
- (z)-n-(2-hydroxyethyl)octadec-9-enamide (325 Da, Ligand)
- Gpr3, guanine nucleotide-binding protein g(s) subunit alpha, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Gpr3-gs-scfv16 complex (150 kDa, Complex from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7xog
Q-score: 0.294
Tan S, Zhao J, Hu X, Li Y, Wu Z, Lu G, Yu Z, Du B, Liu Y, Li L, Chen Y, Li Y, Yao Y, Zhang X, Rao J, Gao G, Peng Y, Liu H, Yuan Z, Liu J, Wang Q, Hu H, Gao X, Zhou H, Yu H, Xu Y, Yu W, Feng L, Wang M, Shan C, Lu J, Lin J
Sci Bull (Beijing) (2023) 68 pp. 3192-3206 [ Pubmed: 37993332 DOI: doi:10.1016/j.scib.2023.11.024 ]
- Alpha-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein,peptide (142 kDa, Protein from synthetic construct)
- Severe acute respiratory syndrome coronavirus (Complex from Severe acute respiratory syndrome coronavirus)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7xoe
Q-score: 0.301
Tan S, Zhao J, Hu X, Li Y, Wu Z, Lu G, Yu Z, Du B, Liu Y, Li L, Chen Y, Li Y, Yao Y, Zhang X, Rao J, Gao G, Peng Y, Liu H, Yuan Z, Liu J, Wang Q, Hu H, Gao X, Zhou H, Yu H, Xu Y, Yu W, Feng L, Wang M, Shan C, Lu J, Lin J
Sci Bull (Beijing) (2023) 68 pp. 3192-3206 [ Pubmed: 37993332 DOI: doi:10.1016/j.scib.2023.11.024 ]
CryoEM structure of the histamine H1 receptor-BRIL/Anti BRIL Fab complex with astemizole
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8x5y
Q-score: 0.463
Wang D, Guo Q, Wu Z, Li M, He B, Du Y, Zhang K, Tao Y
Nat Commun (2024) 15 pp. 84-84 [ Pubmed: 38167898 DOI: doi:10.1038/s41467-023-44477-4 ]
- Histamine h1 receptor,soluble cytochrome b562 (50 kDa, Protein from Homo sapiens)
- Cryoem structure of the histamine h1 receptor-bril/anti bril fab complex with astemizole (Complex from Homo sapiens)
- 1-[(4-fluorophenyl)methyl]-n-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1h-benzimidazol-2-amine (458 Da, Ligand)
CryoEM structure of the histamine H1 receptor-BRIL/Anti BRIL Fab complex with mepyramine
CryoEM structure of the histamine H1 receptor-BRIL/Anti BRIL Fab complex with desloratadine