Curved structure of mPIEZO1-S2472E
Resolution: 4.07 Å
EM Method: Single-particle
Fitted PDBs: 8ixn
Q-score: 0.301
Liu S, Yang X, Chen X, Zhang X, Jiang J, Yuan J, Liu W, Wang L, Zhou H, Wu K, Tian B, Li X, Xiao B
Neuron (2024) [ DOI: doi:10.1016/j.neuron.2024.11.020 Pubmed: 39719701 ]
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- S2472e-curved structure (Complex from Mus musculus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
Flattened structure of mPIEZO1-S2472E
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8ixo
Q-score: 0.445
Liu S, Yang X, Chen X, Zhang X, Jiang J, Yuan J, Liu W, Wang L, Zhou H, Wu K, Tian B, Li X, Xiao B
Neuron (2024) [ DOI: doi:10.1016/j.neuron.2024.11.020 Pubmed: 39719701 ]
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- S2472e-intermediate structure (Complex from Mus musculus)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
the Curved Structure of mPIEZO1 in Lipid Bilayer
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 7wlt
Q-score: 0.462
Yang X, Lin C, Chen X, Li S, Li X, Xiao B
Nature (2022) 604 pp. 377-383 [ Pubmed: 35388220 DOI: doi:10.1038/s41586-022-04574-8 ]
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- The curved structure of mpiezo1 in lipid bilayer (Complex from Mus musculus)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
the Curved Structure of mPIEZO1 in Lipid Bilayer
Resolution: 6.81 Å
EM Method: Single-particle
Fitted PDBs: 7wlu
Q-score: 0.196
Yang X, Lin C, Chen X, Li S, Li X, Xiao B
Nature (2022) 604 pp. 377-383 [ Pubmed: 35388220 DOI: doi:10.1038/s41586-022-04574-8 ]
- The flattened structure of mpiezo1 in lipid bilayer (Complex from Mus musculus)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
Cryo-EM structure of human TMEM120A in the CoASH-bound state
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 7f3t
Q-score: 0.443
Rong Y, Jiang J, Gao Y, Guo J, Song D, Liu W, Zhang M, Zhao Y, Xiao B, Liu Z
eLife (2021) 10 [ Pubmed: 34409941 DOI: doi:10.7554/eLife.71474 ]
- Coenzyme a (767 Da, Ligand)
- Transmembrane protein 120a (44 kDa, Protein from Homo sapiens)
- Transmembrane protein 120a (Cell from Homo sapiens)
Cryo-EM structure of human TMEM120A in the CoASH-free state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7f3u
Q-score: 0.335
Rong Y, Jiang J, Gao Y, Guo J, Song D, Liu W, Zhang M, Zhao Y, Xiao B, Liu Z
eLife (2021) 10 [ Pubmed: 34409941 DOI: doi:10.7554/eLife.71474 ]
- Transmembrane protein 120a (44 kDa, Protein from Homo sapiens)
- Transmembrane protein 120a (Cell from Homo sapiens)
Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6lqi
Q-score: 0.326
Geng J, Liu W, Zhou H, Zhang T, Wang L, Zhang M, Li Y, Shen B, Li X, Xiao B
Neuron (2020) 106 pp. 438- [ DOI: doi:10.1016/j.neuron.2020.02.010 Pubmed: 32142647 ]
- Piezo-type mechanosensitive ion channel component 1 (289 kDa, Protein from Mus musculus)
- Homo-trimer of piezo1.1 (880 kDa, Complex from Mus musculus)
Cryo-EM Structure of the Mammalian Tactile Channel Piezo2
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6kg7
Q-score: 0.437
Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, Li Y, Lei J, Li X, Xiao B
Nature (2019) 573 pp. 225-229 [ DOI: doi:10.1038/s41586-019-1505-8 Pubmed: 31435011 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 2 (325 kDa, Protein from Mus musculus)
- Homo-trimer of piezo2 (1 MDa, Complex from Mus musculus)