the Curved Structure of mPIEZO1 in Lipid Bilayer
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 7wlt
Q-score: 0.462
Yang X, Lin C, Chen X, Li S, Li X, Xiao B
Nature (2022) 604 pp. 377-383 [ DOI: doi:10.1038/s41586-022-04574-8 Pubmed: 35388220 ]
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- The curved structure of mpiezo1 in lipid bilayer (Complex from Mus musculus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
the Curved Structure of mPIEZO1 in Lipid Bilayer
Resolution: 6.81 Å
EM Method: Single-particle
Fitted PDBs: 7wlu
Q-score: 0.196
Yang X, Lin C, Chen X, Li S, Li X, Xiao B
Nature (2022) 604 pp. 377-383 [ DOI: doi:10.1038/s41586-022-04574-8 Pubmed: 35388220 ]
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
- The flattened structure of mpiezo1 in lipid bilayer (Complex from Mus musculus)
Cryo-EM structure of human TMEM120A in the CoASH-bound state
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 7f3t
Q-score: 0.443
Rong Y, Jiang J, Gao Y, Guo J, Song D, Liu W, Zhang M, Zhao Y, Xiao B, Liu Z
eLife (2021) 10 [ DOI: doi:10.7554/eLife.71474 Pubmed: 34409941 ]
- Transmembrane protein 120a (44 kDa, Protein from Homo sapiens)
- Coenzyme a (767 Da, Ligand)
- Transmembrane protein 120a (Cell from Homo sapiens)
Cryo-EM structure of human TMEM120A in the CoASH-free state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7f3u
Q-score: 0.335
Rong Y, Jiang J, Gao Y, Guo J, Song D, Liu W, Zhang M, Zhao Y, Xiao B, Liu Z
eLife (2021) 10 [ DOI: doi:10.7554/eLife.71474 Pubmed: 34409941 ]
- Transmembrane protein 120a (44 kDa, Protein from Homo sapiens)
- Transmembrane protein 120a (Cell from Homo sapiens)
Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6lqi
Q-score: 0.326
Geng J, Liu W, Zhou H, Zhang T, Wang L, Zhang M, Li Y, Shen B, Li X, Xiao B
Neuron (2020) 106 pp. 438- [ Pubmed: 32142647 DOI: doi:10.1016/j.neuron.2020.02.010 ]
- Homo-trimer of piezo1.1 (880 kDa, Complex from Mus musculus)
- Piezo-type mechanosensitive ion channel component 1 (289 kDa, Protein from Mus musculus)
Cryo-EM Structure of the Mammalian Tactile Channel Piezo2
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6kg7
Q-score: 0.437
Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, Li Y, Lei J, Li X, Xiao B
Nature (2019) 573 pp. 225-229 [ Pubmed: 31435011 DOI: doi:10.1038/s41586-019-1505-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Homo-trimer of piezo2 (1 MDa, Complex from Mus musculus)
- Piezo-type mechanosensitive ion channel component 2 (325 kDa, Protein from Mus musculus)
Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6agf
Q-score: 0.526
Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N
Science (2018) 362 [ Pubmed: 30190309 DOI: doi:10.1126/science.aau2486 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Complex of human sodium channel protein type 4 subunit alpha and human sodium channel subunit beta-1 (200 kDa, Complex)
- Sodium channel protein type 4 subunit alpha (212 kDa, Protein from Homo sapiens)
- Human sodium channel protein type 4 subunit alpha (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human sodium channel subunit beta-1 (Complex from Homo sapiens)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)