Cryo-EM structure of the amthamine-bound H2R-Gs complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yut
Q-score: 0.529
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z
Adv Sci (2024) 11 pp. e2310120-e2310120 [ Pubmed: 38647423 DOI: doi:10.1002/advs.202310120 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Histamine h2 receptor (46 kDa, Protein from Homo sapiens)
- Amthamine-bound h2r-gs complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 5-(2-azanylethyl)-4-methyl-1,3-thiazol-2-amine (157 Da, Ligand)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
Cryo-EM structure of the histamine-bound H3R-Gi complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yuu
Q-score: 0.566
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z
Adv Sci (2024) 11 pp. e2310120-e2310120 [ Pubmed: 38647423 DOI: doi:10.1002/advs.202310120 ]
- Histamine h3 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Histamine (111 Da, Ligand)
- Histamine-bound h3r-gi complex (Complex from Homo sapiens)
Cryo-EM structure of the immepip-bound H3R-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8yuv
Q-score: 0.532
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z
Adv Sci (2024) 11 pp. e2310120-e2310120 [ Pubmed: 38647423 DOI: doi:10.1002/advs.202310120 ]
- Histamine h3 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- 4-(1h-imidazol-5-ylmethyl)piperidine (165 Da, Ligand)
- Histamine-bound h3r-gi complex (Complex from Homo sapiens)
Cryo-EM structure of the inactive CD97
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ikj
Q-score: 0.301
Cryo-EM structure of the CD97-G13 complex
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 8ikl
Q-score: 0.59
Mao C, Zhao RJ, Dong YJ, Gao M, Chen LN, Zhang C, Xiao P, Guo J, Qin J, Shen DD, Ji SY, Zang SK, Zhang H, Wang WW, Shen Q, Sun JP, Zhang Y
Mol Cell (2024) 84 pp. 570-583.e7 [ DOI: doi:10.1016/j.molcel.2023.12.020 Pubmed: 38215752 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(13) subunit alpha isoforms short (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Adhesion g protein-coupled receptor e5 (31 kDa, Protein from Homo sapiens)
- Adhesion g protein-coupled receptor e5 (Cellular component from Homo sapiens)
Cryo-EM structure of the TUG891 bound GPR120-Giq complex(mask on receptor)
Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP
Science (2023) 380 pp. eadd6220-eadd6220 [ Pubmed: 36862765 DOI: doi:10.1126/science.add6220 ]
Cryo-EM structure of the TUG891 bound GPR120-Giq complex(mask on Giq-scFV16 complex)
Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP
Science (2023) 380 pp. eadd6220-eadd6220 [ Pubmed: 36862765 DOI: doi:10.1126/science.add6220 ]