Identification, structure and agonist design of an androgen membrane receptor.
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8x9s
Q-score: 0.506
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Complex of gpr133 with agonist and g protein trime (Complex from Bos taurus)
- Adhesion g-protein coupled receptor d1 (65 kDa, Protein from Homo sapiens)
- 5-alpha-dihydrotestosterone (290 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gs protein alpha subunit (41 kDa, Protein from Bos taurus)
Identification, structure and agonist design of an androgen membrane receptor.
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 9iv1
Q-score: 0.478
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- Adhesion g-protein coupled receptor d1 (34 kDa, Protein from Homo sapiens)
- 5-alpha-dihydrotestosterone (290 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Complex of gpr133 with agonist and g protein trime (Complex from Homo sapiens)
- Scfv16 (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Identification, structure and agonist design of an androgen membrane receptor.
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 9iv2
Q-score: 0.503
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- Adhesion g-protein coupled receptor d1 (65 kDa, Protein from Homo sapiens)
- Gs protein alpha subunit (41 kDa, Protein from Homo sapiens)
- 5-alpha-dihydrotestosterone (290 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Complex of gpr133 with agonist and g protein trime (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8xjl
Q-score: 0.559
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Engineered minigq (28 kDa, Protein from synthetic construct)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)
- (z)-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(e,3s)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid (354 Da, Ligand)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Pgf2-alpha-fp-minigq-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Latanoprost acid bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8xjm
Q-score: 0.555
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Engineered minigq (28 kDa, Protein from synthetic construct)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)
- Latanoprost acid-fp-minigq-scfv16 complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Z-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(3r)-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoic acid (390 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
U46619 bound Thromboxane A2 receptor-Gq Protein Complex
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8xjo
Q-score: 0.493
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- U46619-tp-minigq-scfv16 complex (Complex from Homo sapiens)
- Fusion tag,thromboxane a2 receptor,lgbit (61 kDa, Protein from synthetic construct)
- (5z)-7-{(1r,4s,5s,6r)-6-[(1e,3s)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid (350 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered minigq (28 kDa, Protein from synthetic construct)
Cryo-EM structure of the inactive CD97
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ikj
Q-score: 0.301
Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex.
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7ckw
Q-score: 0.431
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- D(1a) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Lama glama)
- Protein-1 (Complex)
- (1r)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (305 Da, Ligand)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Homo sapiens)
- Em stucture of complex-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7ckx
Q-score: 0.389
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- D(1a) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- (1r,3s)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1h-isochromene-5,6-diol (329 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- Em structure of protein-2 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7cky
Q-score: 0.254
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- Complex structure-3 (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (49 kDa, Protein from Homo sapiens)
- 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione (389 Da, Ligand)
- Nanobody 35 (Complex from Lama glama)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)