Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8gd9
Q-score: 0.534
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
- 4-({2-[(1r,2r,3r,5s)-3,5-dihydroxy-2-{(3s)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl}cyclopentyl]ethyl}sulfanyl)butanoic acid (440 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gda
Q-score: 0.506
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
- (2s,5r)-5-[(1e,3s)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1h-tetrazol-5-yl)hexyl]pyrrolidin-2-ol (421 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8gdb
Q-score: 0.57
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8gdc
Q-score: 0.401
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep3 subtype (43 kDa, Protein from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8gcm
Q-score: 0.482
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- Cryo-em structure of prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (5s)-5-[(3r)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1h-tetrazol-5-yl)hexyl]pyrrolidin-2-one (421 Da, Ligand)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8gcp
Q-score: 0.463
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- Scfv (32 kDa, Protein from Homo sapiens)
- Cryo-em structure of prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
RBD-1 of SARS-CoV-2 Beta spike in complex with S5D2 Fab
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wcr
Q-score: 0.354
Xu S, Wang Y, Wang Y, Zhang C, Hong Q, Gu C, Xu R, Wang T, Yang Y, Zang J, Zhou Y, Li Z, Liu Q, Zhou B, Bai L, Zhu Y, Deng Q, Wang H, Lavillette D, Wong G, Xie Y, Cong Y, Huang Z
Emerg Microbes Infect (2022) 11 pp. 351-367 [ Pubmed: 34964428 DOI: doi:10.1080/22221751.2021.2024455 ]
- Rbd-1 of sars-cov-2 beta spike in complex with s5d2 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein (Complex from Mus musculus)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of s5d2 fab (23 kDa, Protein from Mus musculus)
- Light chain of s5d2 fab (24 kDa, Protein from Mus musculus)
- Light chain of s5d2 fab (Complex)
- Heavy chain of s5d2 fab (Complex from Mus musculus)
SARS-CoV-2 Beta spike in complex with one S5D2 Fab
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wcz
Q-score: 0.256
Xu S, Wang Y, Wang Y, Zhang C, Hong Q, Gu C, Xu R, Wang T, Yang Y, Zang J, Zhou Y, Li Z, Liu Q, Zhou B, Bai L, Zhu Y, Deng Q, Wang H, Lavillette D, Wong G, Xie Y, Cong Y, Huang Z
Emerg Microbes Infect (2022) 11 pp. 351-367 [ Pubmed: 34964428 DOI: doi:10.1080/22221751.2021.2024455 ]
- Sars-cov-2 spike protein (Complex from Mus musculus)
- Heavy chain of s5d2 fab (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 beta spike in complex with one s5d2 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of s5d2 fab (24 kDa, Protein from Mus musculus)
- Light chain of s5d2 fab (Complex)
- Heavy chain of s5d2 fab (Complex from Mus musculus)
SARS-CoV-2 Beta spike in complex with two S5D2 Fabs
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7wd0
Q-score: 0.291
Xu S, Wang Y, Wang Y, Zhang C, Hong Q, Gu C, Xu R, Wang T, Yang Y, Zang J, Zhou Y, Li Z, Liu Q, Zhou B, Bai L, Zhu Y, Deng Q, Wang H, Lavillette D, Wong G, Xie Y, Cong Y, Huang Z
Emerg Microbes Infect (2022) 11 pp. 351-367 [ Pubmed: 34964428 DOI: doi:10.1080/22221751.2021.2024455 ]
- Sars-cov-2 spike protein (Complex from Mus musculus)
- Sars-cov-2 beta spike in complex with two s5d2 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of s5d2 fab (23 kDa, Protein from Mus musculus)
- Light chain of s5d2 fab (24 kDa, Protein from Mus musculus)
- Light chain of s5d2 fab (Complex)
- Heavy chain of s5d2 fab (Complex from Mus musculus)
SARS-CoV-2 Beta spike in complex with three S5D2 Fabs
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wd7
Q-score: 0.22
Xu S, Wang Y, Wang Y, Zhang C, Hong Q, Gu C, Xu R, Wang T, Yang Y, Zang J, Zhou Y, Li Z, Liu Q, Zhou B, Bai L, Zhu Y, Deng Q, Wang H, Lavillette D, Wong G, Xie Y, Cong Y, Huang Z
Emerg Microbes Infect (2022) 11 pp. 351-367 [ Pubmed: 34964428 DOI: doi:10.1080/22221751.2021.2024455 ]
- Light chain of s5d2 fab (Complex from Mus musculus)
- Sars-cov-2 spike protein (Complex from Mus musculus)
- Sars-cov-2 beta spike in complex with two s5d2 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of s5d2 fab (Complex)
- Heavy chain of s5d2 fab (23 kDa, Protein from Mus musculus)
- Light chain of s5d2 fab (24 kDa, Protein from Mus musculus)