SARS-CoV-2 RBD + IMCAS-123 + IMCAS-72 Fab
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8xse
Q-score: 0.531
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Imcas-72 h chain (24 kDa, Protein from Homo sapiens)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Imcas-72 l chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 rbd + imcas-123 + imcas-72 fab (Complex)
- Imcas-123 h chain (23 kDa, Protein from Homo sapiens)
- Imcas-123 + imcas-72 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Imcas-123 l chain (23 kDa, Protein from Homo sapiens)
SARS-CoV-2 RBD + IMCAS-364 + hACE2
Resolution: 2.16 Å
EM Method: Single-particle
Fitted PDBs: 8xsf
Q-score: 0.416
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Imcas-364 (Complex from Homo sapiens)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ace2 (Complex from Homo sapiens)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Imcas-364 h chain (50 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
- Imcas-364 l chain (23 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 rbd + imcas-364 + hace2 (global refinement) (Complex)
SARS-CoV-2 RBD + IMCAS-364 (Local Refinement)
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 8xsi
Q-score: 0.555
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Imcas-364 (Complex from Homo sapiens)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cryo-em structure of sars-cov-2 rbd + imcas-364 (local refinement) (Complex)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Imcas-364 h chain (50 kDa, Protein from Homo sapiens)
- Imcas-364 l chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Omicron BA.4 RBD + IMCAS-316 + ACE2
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8xsj
Q-score: 0.453
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Cryo-em structure of sars-cov-2 omicron ba.4 rbd + imcas-316 + ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Imcas-316 h chain (24 kDa, Protein from Homo sapiens)
- Imcas-316 l chain (23 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xsl
Q-score: 0.359
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ DOI: doi:10.1016/j.celrep.2024.114338 Pubmed: 38850530 ]
- Cryo-em structure of sars-cov-2 spike + imcas-123 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Imcas-123 heavy chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Imcas-123 light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of the 123-316 scDb/PT-RBD complex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8y0y
Q-score: 0.533
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- The 123-316 scdb/pt-rbd complex (Complex from Homo sapiens)
- 123-316 scdb (56 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)