CryoEM structure of sNS1 complexed with Fab 4F10
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jqm
Q-score: 0.624
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- Zikv ns1 (Complex from Zika virus)
- 4f10 fab heavy chain (13 kDa, Protein from Homo sapiens)
- 4f10 fab light chain (11 kDa, Protein from Homo sapiens)
- The complex of zikv ns1 with antibody 4f10 (Complex)
- Antibody 4f10 (Complex from Homo sapiens)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
CryoEM structure of sNS1 complexed with Fab 3G2
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8jkf
Q-score: 0.581
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- Zikv ns1 (Complex from Zika virus)
- The heavy chain of antibody 3g2 (12 kDa, Protein from Homo sapiens)
- Ns1 (40 kDa, Protein from Zika virus)
- The complex of zikv ns1 with antibody 3g2 (Complex)
- Antibody 3g2 (Complex from Homo sapiens)
- The light chain of antibody 3g2 (11 kDa, Protein from Homo sapiens)
CryoEM structure of sNS1 complexed with Fab 2E11
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jqn
Q-score: 0.605
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- Zikv ns1 (Complex from Zika virus)
- The complex of zikv ns1 with antibody 2e11 (Complex)
- 2e11 fab light chain (11 kDa, Protein from Homo sapiens)
- Antibody 2e11 (Complex from Homo sapiens)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
- 2e11 fab heavy chain (12 kDa, Protein from Homo sapiens)
CryoEM structure of sNS1 complexed with Fab 4B8
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8jkh
Q-score: 0.569
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- Antibody 4b8 (Complex from Homo sapiens)
- Zikv ns1 (Complex from Zika virus)
- The heavy chain of antibody 4b8 (12 kDa, Protein from Homo sapiens)
- Ns1 (40 kDa, Protein from Zika virus)
- The complex of zikv ns1 with antibody 4b8 (Complex)
- The light chain of antibody 4b8 (11 kDa, Protein from Homo sapiens)
CryoEM structure of sNS1 complexed with Fab 14G5
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8jqs
Q-score: 0.569
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- Zikv ns1 (Complex from Zika virus)
- Antibody 14g5 (Complex from Homo sapiens)
- 14g5 fab light chain (11 kDa, Protein from Homo sapiens)
- The complex of zikv ns1 with antibody 14g5 (Complex)
- 14g5 fab heavy chain (12 kDa, Protein from Homo sapiens)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
Cryo-EM structure of human ABCC4
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8xok
Q-score: 0.438
Zhu Y, Xing X, Wang F, Chen L, Zhong C, Lu X, Yu Z, Yang Y, Yao Y, Song Q, Han S, Liu Z, Zhang P
FEBS Lett (2024) 598 pp. 1967-1980 [ DOI: doi:10.1002/1873-3468.14955 Pubmed: 38886124 ]
- Palmitic acid (256 Da, Ligand)
- Apo human abcc4 (149 kDa, Cellular component from Homo sapiens)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Atp-binding cassette sub-family c member 4 (149 kDa, Protein from Homo sapiens)
Cryo-EM structure of human ABCC4 with ANP bound in NBD1
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8xol
Q-score: 0.385
Zhu Y, Xing X, Wang F, Chen L, Zhong C, Lu X, Yu Z, Yang Y, Yao Y, Song Q, Han S, Liu Z, Zhang P
FEBS Lett (2024) 598 pp. 1967-1980 [ Pubmed: 38886124 DOI: doi:10.1002/1873-3468.14955 ]
- Palmitic acid (256 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Human abcc4 in complex with anp-bound in nbd1 (149 kDa, Cellular component from Homo sapiens)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Atp-binding cassette sub-family c member 4 (149 kDa, Protein from Homo sapiens)
Cryo-EM structure of human ABCC4 in complex with ANP-bound in NBD1 and METHOTREXATE
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8xom
Q-score: 0.365
Zhu Y, Xing X, Wang F, Chen L, Zhong C, Lu X, Yu Z, Yang Y, Yao Y, Song Q, Han S, Liu Z, Zhang P
FEBS Lett (2024) 598 pp. 1967-1980 [ Pubmed: 38886124 DOI: doi:10.1002/1873-3468.14955 ]
- Palmitic acid (256 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Methotrexate (454 Da, Ligand)
- Atp-binding cassette sub-family c member 4 (149 kDa, Protein from Homo sapiens)
- Human abcc4 in complex with anp-bound in nbd1 and mtx (149 kDa, Cellular component from Homo sapiens)
SARS-CoV-2 RBD + IMCAS-123 + IMCAS-72 Fab
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8xse
Q-score: 0.531
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Imcas-72 h chain (24 kDa, Protein from Homo sapiens)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Imcas-72 l chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 rbd + imcas-123 + imcas-72 fab (Complex)
- Imcas-123 h chain (23 kDa, Protein from Homo sapiens)
- Imcas-123 + imcas-72 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Imcas-123 l chain (23 kDa, Protein from Homo sapiens)
SARS-CoV-2 RBD + IMCAS-364 + hACE2
Resolution: 2.16 Å
EM Method: Single-particle
Fitted PDBs: 8xsf
Q-score: 0.416
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ Pubmed: 38850530 DOI: doi:10.1016/j.celrep.2024.114338 ]
- Imcas-364 (Complex from Homo sapiens)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ace2 (Complex from Homo sapiens)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Imcas-364 h chain (50 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
- Imcas-364 l chain (23 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 rbd + imcas-364 + hace2 (global refinement) (Complex)