CryoEM structure of sNS1 complexed with Fab 4F10
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jqm
Q-score: 0.624
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- 4f10 fab heavy chain (13 kDa, Protein from Homo sapiens)
- The complex of zikv ns1 with antibody 4f10 (Complex)
- 4f10 fab light chain (11 kDa, Protein from Homo sapiens)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
- Antibody 4f10 (Complex from Homo sapiens)
- Zikv ns1 (Complex from Zika virus)
CryoEM structure of sNS1 complexed with Fab 2E11
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jqn
Q-score: 0.605
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- Antibody 2e11 (Complex from Homo sapiens)
- The complex of zikv ns1 with antibody 2e11 (Complex)
- 2e11 fab light chain (11 kDa, Protein from Homo sapiens)
- 2e11 fab heavy chain (12 kDa, Protein from Homo sapiens)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
- Zikv ns1 (Complex from Zika virus)
CryoEM structure of sNS1 complexed with Fab 14G5
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8jqs
Q-score: 0.569
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- 14g5 fab heavy chain (12 kDa, Protein from Homo sapiens)
- Antibody 14g5 (Complex from Homo sapiens)
- The complex of zikv ns1 with antibody 14g5 (Complex)
- 14g5 fab light chain (11 kDa, Protein from Homo sapiens)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
- Zikv ns1 (Complex from Zika virus)
Cryo-EM structure of human ABCC4
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8xok
Q-score: 0.438
Zhu Y, Xing X, Wang F, Chen L, Zhong C, Lu X, Yu Z, Yang Y, Yao Y, Song Q, Han S, Liu Z, Zhang P
FEBS Lett (2024) 598 pp. 1967-1980 [ Pubmed: 38886124 DOI: doi:10.1002/1873-3468.14955 ]
- Apo human abcc4 (149 kDa, Cellular component from Homo sapiens)
- Atp-binding cassette sub-family c member 4 (149 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
Cryo-EM structure of human ABCC4 with ANP bound in NBD1
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8xol
Q-score: 0.385
Zhu Y, Xing X, Wang F, Chen L, Zhong C, Lu X, Yu Z, Yang Y, Yao Y, Song Q, Han S, Liu Z, Zhang P
FEBS Lett (2024) 598 pp. 1967-1980 [ Pubmed: 38886124 DOI: doi:10.1002/1873-3468.14955 ]
- Palmitic acid (256 Da, Ligand)
- Human abcc4 in complex with anp-bound in nbd1 (149 kDa, Cellular component from Homo sapiens)
- Atp-binding cassette sub-family c member 4 (149 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
Cryo-EM structure of human ABCC4 in complex with ANP-bound in NBD1 and METHOTREXATE
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8xom
Q-score: 0.365
Zhu Y, Xing X, Wang F, Chen L, Zhong C, Lu X, Yu Z, Yang Y, Yao Y, Song Q, Han S, Liu Z, Zhang P
FEBS Lett (2024) 598 pp. 1967-1980 [ Pubmed: 38886124 DOI: doi:10.1002/1873-3468.14955 ]
- Human abcc4 in complex with anp-bound in nbd1 and mtx (149 kDa, Cellular component from Homo sapiens)
- Methotrexate (454 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Atp-binding cassette sub-family c member 4 (149 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
SARS-CoV-2 RBD + IMCAS-123 + IMCAS-72 Fab
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8xse
Q-score: 0.531
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ DOI: doi:10.1016/j.celrep.2024.114338 Pubmed: 38850530 ]
- Imcas-123 l chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 rbd + imcas-123 + imcas-72 fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Imcas-123 + imcas-72 fab (Complex from Homo sapiens)
- Imcas-72 h chain (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Imcas-123 h chain (23 kDa, Protein from Homo sapiens)
- Imcas-72 l chain (23 kDa, Protein from Homo sapiens)
SARS-CoV-2 RBD + IMCAS-364 + hACE2
Resolution: 2.16 Å
EM Method: Single-particle
Fitted PDBs: 8xsf
Q-score: 0.416
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ DOI: doi:10.1016/j.celrep.2024.114338 Pubmed: 38850530 ]
- Imcas-364 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Imcas-364 h chain (50 kDa, Protein from Homo sapiens)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Imcas-364 l chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 rbd + imcas-364 + hace2 (global refinement) (Complex)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
- Ace2 (Complex from Homo sapiens)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron BA.4 RBD + IMCAS-316 + ACE2
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8xsj
Q-score: 0.453
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ DOI: doi:10.1016/j.celrep.2024.114338 Pubmed: 38850530 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 omicron ba.4 rbd + imcas-316 + ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
- Imcas-316 l chain (23 kDa, Protein from Homo sapiens)
- Imcas-316 h chain (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the 123-316 scDb/PT-RBD complex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8y0y
Q-score: 0.533
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ DOI: doi:10.1016/j.celrep.2024.114338 Pubmed: 38850530 ]
- The 123-316 scdb/pt-rbd complex (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 123-316 scdb (56 kDa, Protein from Homo sapiens)