CryoEM structure of sNS1 complexed with Fab 4F10
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jqm
Q-score: 0.624
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- 4f10 fab heavy chain (13 kDa, Protein from Homo sapiens)
- The complex of zikv ns1 with antibody 4f10 (Complex)
- 4f10 fab light chain (11 kDa, Protein from Homo sapiens)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
- Antibody 4f10 (Complex from Homo sapiens)
- Zikv ns1 (Complex from Zika virus)
CryoEM structure of sNS1 complexed with Fab 3G2
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8jkf
Q-score: 0.581
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- The complex of zikv ns1 with antibody 3g2 (Complex)
- Antibody 3g2 (Complex from Homo sapiens)
- The heavy chain of antibody 3g2 (12 kDa, Protein from Homo sapiens)
- Ns1 (40 kDa, Protein from Zika virus)
- The light chain of antibody 3g2 (11 kDa, Protein from Homo sapiens)
- Zikv ns1 (Complex from Zika virus)
CryoEM structure of sNS1 complexed with Fab 2E11
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jqn
Q-score: 0.605
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- Antibody 2e11 (Complex from Homo sapiens)
- The complex of zikv ns1 with antibody 2e11 (Complex)
- 2e11 fab light chain (11 kDa, Protein from Homo sapiens)
- 2e11 fab heavy chain (12 kDa, Protein from Homo sapiens)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
- Zikv ns1 (Complex from Zika virus)
CryoEM structure of sNS1 complexed with Fab 4B8
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8jkh
Q-score: 0.569
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- Ns1 (40 kDa, Protein from Zika virus)
- The light chain of antibody 4b8 (11 kDa, Protein from Homo sapiens)
- Antibody 4b8 (Complex from Homo sapiens)
- Zikv ns1 (Complex from Zika virus)
- The complex of zikv ns1 with antibody 4b8 (Complex)
- The heavy chain of antibody 4b8 (12 kDa, Protein from Homo sapiens)
CryoEM structure of sNS1 complexed with Fab 14G5
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8jqs
Q-score: 0.569
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- 14g5 fab heavy chain (12 kDa, Protein from Homo sapiens)
- Antibody 14g5 (Complex from Homo sapiens)
- The complex of zikv ns1 with antibody 14g5 (Complex)
- 14g5 fab light chain (11 kDa, Protein from Homo sapiens)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
- Zikv ns1 (Complex from Zika virus)
SARS-CoV-2 RBD + IMCAS-123 + IMCAS-72 Fab
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8xse
Q-score: 0.531
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ DOI: doi:10.1016/j.celrep.2024.114338 Pubmed: 38850530 ]
- Imcas-123 l chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 rbd + imcas-123 + imcas-72 fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Imcas-123 + imcas-72 fab (Complex from Homo sapiens)
- Imcas-72 h chain (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Imcas-123 h chain (23 kDa, Protein from Homo sapiens)
- Imcas-72 l chain (23 kDa, Protein from Homo sapiens)
SARS-CoV-2 RBD + IMCAS-364 + hACE2
Resolution: 2.16 Å
EM Method: Single-particle
Fitted PDBs: 8xsf
Q-score: 0.416
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ DOI: doi:10.1016/j.celrep.2024.114338 Pubmed: 38850530 ]
- Imcas-364 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Imcas-364 h chain (50 kDa, Protein from Homo sapiens)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Imcas-364 l chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 rbd + imcas-364 + hace2 (global refinement) (Complex)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
- Ace2 (Complex from Homo sapiens)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 RBD + IMCAS-364 (Local Refinement)
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 8xsi
Q-score: 0.555
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ DOI: doi:10.1016/j.celrep.2024.114338 Pubmed: 38850530 ]
- Imcas-364 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Imcas-364 h chain (50 kDa, Protein from Homo sapiens)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Imcas-364 l chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 rbd + imcas-364 (local refinement) (Complex)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron BA.4 RBD + IMCAS-316 + ACE2
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8xsj
Q-score: 0.453
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ DOI: doi:10.1016/j.celrep.2024.114338 Pubmed: 38850530 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 omicron ba.4 rbd + imcas-316 + ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
- Imcas-316 l chain (23 kDa, Protein from Homo sapiens)
- Imcas-316 h chain (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xsl
Q-score: 0.359
Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF
Cell Rep (2024) 43 pp. 114338-114338 [ DOI: doi:10.1016/j.celrep.2024.114338 Pubmed: 38850530 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cryo-em structure of sars-cov-2 spike + imcas-123 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Imcas-123 heavy chain (23 kDa, Protein from Homo sapiens)
- Imcas-123 light chain (23 kDa, Protein from Homo sapiens)