Gi bound CCR8 complex with nonpeptide agonist LMD-009
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8kfx
Q-score: 0.496
Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F
Sci Adv (2024) 10 pp. eadj7500-eadj7500 [ DOI: doi:10.1126/sciadv.adj7500 Pubmed: 38306437 ]
- C-c chemokine receptor type 8,fusion protein (65 kDa, Protein from synthetic construct)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpcr gi complex with agonist (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 8-[[3-(2-methoxyphenoxy)phenyl]methyl]-1-(2-phenylethyl)-1,3,8-triazaspiro[4.5]decan-4-one (471 Da, Ligand)
Gi bound CCR8 complex with nonpeptide agonist ZK 756326
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8kfy
Q-score: 0.466
Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F
Sci Adv (2024) 10 pp. eadj7500-eadj7500 [ Pubmed: 38306437 DOI: doi:10.1126/sciadv.adj7500 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Hetero complex (Complex from Homo sapiens)
- C-c chemokine receptor type 8,fusion protein (65 kDa, Protein from synthetic construct)
- 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol (356 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Gi bound CCR8 in ligand free state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8kfz
Q-score: 0.351
Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F
Sci Adv (2024) 10 pp. eadj7500-eadj7500 [ DOI: doi:10.1126/sciadv.adj7500 Pubmed: 38306437 ]
- Hetero complex (Complex from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- C-c chemokine receptor type 8,lgbit fusion protein,recombinant human rhinovirus (65 kDa, Protein from synthetic construct)
Orphan GPR20 in complex with Fab046
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8hs2
Q-score: 0.479
Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F
Cell Discov (2023) 9 pp. 23-23 [ DOI: doi:10.1038/s41421-023-00520-8 Pubmed: 36849514 ]
- Light chain of fab046 (25 kDa, Protein from Rattus)
- The complex of gpr20 with fab046 (Complex from Homo sapiens)
- Heavy chain of fab046 (26 kDa, Protein from Rattus)
- Soluble cytochrome b562,g-protein coupled receptor 20 (50 kDa, Protein from Homo sapiens)
Gi bound orphan GPR20 in ligand-free state
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8hs3
Q-score: 0.483
Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F
Cell Discov (2023) 9 pp. 23-23 [ DOI: doi:10.1038/s41421-023-00520-8 Pubmed: 36849514 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Ggama (8 kDa, Protein from Homo sapiens)
- Orphan gpr20 complex with gi trimer in the absence of a ligand (Complex from Homo sapiens)
- Soluble cytochrome b562,g-protein coupled receptor 20 (56 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
Gi bound Orphan GPR20 complex with Fab046 in ligand-free state
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8hsc
Q-score: 0.467
Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F
Cell Discov (2023) 9 pp. 23-23 [ Pubmed: 36849514 DOI: doi:10.1038/s41421-023-00520-8 ]
- The complex of gi bound orphan gpr20 with fab046 (Complex from Homo sapiens)
- Light chain of fab046 (25 kDa, Protein from Rattus)
- Soluble cytochrome b562,g-protein coupled receptor 20 (56 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Vicugna pacos)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Heavy chain of fab046 (25 kDa, Protein from Rattus)
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 6sj7
Q-score: 0.46
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J
Nat Chem Biol (2020) 16 pp. 15-23 [ Pubmed: 31819272 DOI: doi:10.1038/s41589-019-0411-6 ]
- Ddb1 complex (210 kDa, Complex)
- Det1- and ddb1-associated protein 1 (11 kDa, Protein from Homo sapiens)
- Rbm39 (Complex from Homo sapiens)
- Ddb1-dda1-dcaf15-rbm39 complex (Complex from Homo sapiens)
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
- Ddb1- and cul4-associated factor 15 (66 kDa, Protein from Homo sapiens)
- N~1~-(3-chloro-1h-indol-7-yl)benzene-1,4-disulfonamide (385 Da, Ligand)
- Rna binding protein 39 (9 kDa, Protein from Homo sapiens)