Orphan receptor GPRC5D in complex with scFv150-18
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8yzk
Q-score: 0.31
Yan P, Lin X, Wu L, Xu L, Li F, Liu J, Xu F
Nat Commun (2024) 15 pp. 5255-5255 [ DOI: doi:10.1038/s41467-024-49625-y Pubmed: 38898050 ]
- Soluble cytochrome b562,g-protein coupled receptor family c group 5 member d (47 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Complex of orphan gprc5d with scfv150-18 (Complex from Homo sapiens)
Gi bound CCR8 complex with nonpeptide agonist LMD-009
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8kfx
Q-score: 0.496
Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F
Sci Adv (2024) 10 pp. eadj7500-eadj7500 [ DOI: doi:10.1126/sciadv.adj7500 Pubmed: 38306437 ]
- C-c chemokine receptor type 8,fusion protein (65 kDa, Protein from synthetic construct)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpcr gi complex with agonist (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 8-[[3-(2-methoxyphenoxy)phenyl]methyl]-1-(2-phenylethyl)-1,3,8-triazaspiro[4.5]decan-4-one (471 Da, Ligand)
Gi bound CCR8 complex with nonpeptide agonist ZK 756326
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8kfy
Q-score: 0.466
Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F
Sci Adv (2024) 10 pp. eadj7500-eadj7500 [ Pubmed: 38306437 DOI: doi:10.1126/sciadv.adj7500 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Hetero complex (Complex from Homo sapiens)
- C-c chemokine receptor type 8,fusion protein (65 kDa, Protein from synthetic construct)
- 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol (356 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Gi bound CCR8 in ligand free state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8kfz
Q-score: 0.351
Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F
Sci Adv (2024) 10 pp. eadj7500-eadj7500 [ DOI: doi:10.1126/sciadv.adj7500 Pubmed: 38306437 ]
- Hetero complex (Complex from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- C-c chemokine receptor type 8,lgbit fusion protein,recombinant human rhinovirus (65 kDa, Protein from synthetic construct)
Gq bound FZD1 in ligand-free state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8j9n
Q-score: 0.386
Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F
Cell Discov (2024) 10 pp. 3-3 [ Pubmed: 38182578 DOI: doi:10.1038/s41421-023-00627-y ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(q) subunit alpha (28 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Vicugna pacos)
- Fzd1-gq complex in the ligand-free state (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Frizzled-1 (64 kDa, Protein from Homo sapiens)
Cryo-EM structure of inactive FZD1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8j9o
Q-score: 0.347
Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F
Cell Discov (2024) 10 pp. 3-3 [ Pubmed: 38182578 DOI: doi:10.1038/s41421-023-00627-y ]
- Frizzled-1,soluble cytochrome b562 (75 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (13 kDa, Protein from Vicugna pacos)
- Anti-bril fab heavy chain (28 kDa, Protein from Mus)
- Frizzled-1 with icl3-bril complex with anti-bril fab (Complex from Homo sapiens)
- Anti-bril fab light chain (24 kDa, Protein from Mus)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8jh7
Q-score: 0.354
Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F
Cell Discov (2024) 10 pp. 3-3 [ Pubmed: 38182578 DOI: doi:10.1038/s41421-023-00627-y ]
- Anti-bril fab heavy chain (25 kDa, Protein from Homo sapiens)
- Complex of human fzd6 in inactivate state with accessory proteins. (Complex from Homo sapiens)
- Anti-fab nanobody (14 kDa, Protein from synthetic construct)
- Anti-bril fab light chain (23 kDa, Protein from Homo sapiens)
- Frizzled-6,soluble cytochrome b562 (73 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jhb
Q-score: 0.334
Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F
Cell Discov (2024) 10 pp. 3-3 [ Pubmed: 38182578 DOI: doi:10.1038/s41421-023-00627-y ]
- Frizzled-6 (61 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Fzd6-gs complex with nb35. (Complex from Homo sapiens)
- Nb35 (14 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (31 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jhc
Q-score: 0.387
Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F
Cell Discov (2024) 10 pp. 3-3 [ Pubmed: 38182578 DOI: doi:10.1038/s41421-023-00627-y ]
- Anti-fab nanobody (14 kDa, Protein from synthetic construct)
- Frizzled-3,soluble cytochrome b562 (74 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (25 kDa, Protein from Homo sapiens)
- Complex of fzd3 with anti-bril fab and anti-fab nanobody (Complex from Homo sapiens)
- Anti-bril fab light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8jhi
Q-score: 0.423
Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F
Cell Discov (2024) 10 pp. 3-3 [ Pubmed: 38182578 DOI: doi:10.1038/s41421-023-00627-y ]
- Nb35 (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Complex of fzd3-gs heterotrimer with nb35. (Complex from Homo sapiens)
- Frizzled-3 (60 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (28 kDa, Protein from Homo sapiens)