Cryo-EM structure of human dimeric APJR-Gi complex with apelin-13.
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8xqe
Q-score: 0.304
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ Pubmed: 39747115 DOI: doi:10.1038/s41467-024-55555-6 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G protein subunit alpha i1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Dimeric apjr-gi complex with apelin-13 (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
Cryo-EM structure of human monomeric APJR-Gi complex with apelin-13.
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8xqf
Q-score: 0.405
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ Pubmed: 39747115 DOI: doi:10.1038/s41467-024-55555-6 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G protein subunit alpha i1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Monomeric apjr-gi complex with apelin-13 (Complex from Homo sapiens)
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
Cryo-EM structure of human dimeric Apelin receptor.
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8xqi
Q-score: 0.454
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ Pubmed: 39747115 DOI: doi:10.1038/s41467-024-55555-6 ]
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Homodimer of apelin receptor (Complex from Homo sapiens)
Cryo-EM structure of human dimeric APJR complex with antagonistic antibody
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8xqj
Q-score: 0.444
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ Pubmed: 39747115 DOI: doi:10.1038/s41467-024-55555-6 ]
- Jn241 (17 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Apjr complex with antibody (Complex from Homo sapiens)
Cryo-EM structure of APJR complex with agonistic antibody
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8z74
Q-score: 0.394
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ Pubmed: 39747115 DOI: doi:10.1038/s41467-024-55555-6 ]
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Agonistic antibody (13 kDa, Protein from Homo sapiens)
- Apjr complex with antibody (Complex from Homo sapiens)
Cryo-EM structure of APJR-Gi complex with agonistic antibody
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8z7j
Q-score: 0.388
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ Pubmed: 39747115 DOI: doi:10.1038/s41467-024-55555-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Agonistic antibody (13 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Apjr complexed with gi (Complex from Homo sapiens)
Orphan receptor GPRC5D in complex with scFv150-18
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8yzk
Q-score: 0.31
Yan P, Lin X, Wu L, Xu L, Li F, Liu J, Xu F
Nat Commun (2024) 15 pp. 5255-5255 [ DOI: doi:10.1038/s41467-024-49625-y Pubmed: 38898050 ]
- Soluble cytochrome b562,g-protein coupled receptor family c group 5 member d (47 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Complex of orphan gprc5d with scfv150-18 (Complex from Homo sapiens)
Gi bound CCR8 complex with nonpeptide agonist LMD-009
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8kfx
Q-score: 0.496
Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F
Sci Adv (2024) 10 pp. eadj7500-eadj7500 [ Pubmed: 38306437 DOI: doi:10.1126/sciadv.adj7500 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Gpcr gi complex with agonist (Complex from Homo sapiens)
- C-c chemokine receptor type 8,fusion protein (65 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 8-[[3-(2-methoxyphenoxy)phenyl]methyl]-1-(2-phenylethyl)-1,3,8-triazaspiro[4.5]decan-4-one (471 Da, Ligand)
Gi bound CCR8 complex with nonpeptide agonist ZK 756326
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8kfy
Q-score: 0.466
Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F
Sci Adv (2024) 10 pp. eadj7500-eadj7500 [ Pubmed: 38306437 DOI: doi:10.1126/sciadv.adj7500 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Hetero complex (Complex from Homo sapiens)
- C-c chemokine receptor type 8,fusion protein (65 kDa, Protein from synthetic construct)
- 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol (356 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Gi bound CCR8 in ligand free state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8kfz
Q-score: 0.351
Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F
Sci Adv (2024) 10 pp. eadj7500-eadj7500 [ Pubmed: 38306437 DOI: doi:10.1126/sciadv.adj7500 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Hetero complex (Complex from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- C-c chemokine receptor type 8,lgbit fusion protein,recombinant human rhinovirus (65 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)