Cryo-EM structure of the METH-TAAR1 complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w87
Q-score: 0.567
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ Pubmed: 37935377 DOI: doi:10.1038/s41586-023-06775-1 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the meth-taar1 complex (Complex from Homo sapiens)
- Trace amine-associated receptor 1 (39 kDa, Protein from Homo sapiens)
- (2s)-n-methyl-1-phenylpropan-2-amine (149 Da, Ligand)
Cryo-EM structure of the SEP363856-bound TAAR1-Gs complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8w88
Q-score: 0.59
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ Pubmed: 37935377 DOI: doi:10.1038/s41586-023-06775-1 ]
- Cholesterol (386 Da, Ligand)
- Trace amine-associated receptor 1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Sep363856-bound taar1-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Nanobody35 (15 kDa, Protein from Lama glama)
Cryo-EM structure of the PEA-bound TAAR1-Gs complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8w89
Q-score: 0.507
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ Pubmed: 37935377 DOI: doi:10.1038/s41586-023-06775-1 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 1 (39 kDa, Protein from Homo sapiens)
- Cryo-em structure of the pea-bound taar1-gs complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- 2-phenylethylamine (122 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
Cryo-EM structure of the RO5256390-TAAR1 complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w8a
Q-score: 0.551
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ Pubmed: 37935377 DOI: doi:10.1038/s41586-023-06775-1 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 1 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the ro5256390-taar1 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (4s)-4-[(2s)-2-phenylbutyl]-1,3-oxazolidin-2-imine (218 Da, Ligand)
- Nanobody35 (15 kDa, Protein from Lama glama)
Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8w8b
Q-score: 0.55
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ Pubmed: 37935377 DOI: doi:10.1038/s41586-023-06775-1 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Cryo-em structure of sep-363856 bounded serotonin 1a (5-ht1a) receptor-gi protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a (60 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Antibody fragment scfv16 (28 kDa, Protein from Homo sapiens)
Structure of human KCNQ4-ML213 complex with PIP2
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 7vnp
Q-score: 0.376
Zheng Y, Liu H, Chen Y, Dong S, Wang F, Wang S, Li GL, Shu Y, Xu F
Neuron (2022) 110 pp. 237- [ DOI: doi:10.1016/j.neuron.2021.10.029 Pubmed: 34767770 ]
- Kcnq4-ml213 complex with pip2 (Complex from Homo sapiens)
- (1s,2s,4r)-n-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid (257 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 4,maltodextrin-binding protein (116 kDa, Protein from Escherichia coli (strain B / BL21-DE3))
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Calmodulin-3 (16 kDa, Protein from Homo sapiens)
Structure of human KCNQ4-ML213 complex in nanodisc
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 7vnq
Q-score: 0.238
Zheng Y, Liu H, Chen Y, Dong S, Wang F, Wang S, Li GL, Shu Y, Xu F
Neuron (2022) 110 pp. 237- [ Pubmed: 34767770 DOI: doi:10.1016/j.neuron.2021.10.029 ]
- Kcnq4-ml213 complex in nanodisc (Complex from Homo sapiens)
- Calmodulin-3 (16 kDa, Protein from Homo sapiens)
- (1s,2s,4r)-n-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid (257 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 4,maltodextrin-binding protein (116 kDa, Protein from Escherichia coli (strain B / BL21-DE3))
Structure of human KCNQ4-ML213 complex in digitonin
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7vnr
Q-score: 0.27
Zheng Y, Liu H, Chen Y, Dong S, Wang F, Wang S, Li GL, Shu Y, Xu F
Neuron (2022) 110 pp. 237- [ Pubmed: 34767770 DOI: doi:10.1016/j.neuron.2021.10.029 ]
- Calmodulin-3 (16 kDa, Protein from Homo sapiens)
- Kcnq4-ml213 complex in digitonin (Complex from Homo sapiens)
- (1s,2s,4r)-n-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid (257 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 4,maltodextrin-binding protein (116 kDa, Protein from Escherichia coli (strain B / BL21-DE3))