cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7w77
Q-score: 0.449
Li X, Xu F, Xu H, Zhang S, Gao Y, Zhang H, Dong Y, Zheng Y, Yang B, Sun J, Zhang XC, Zhao Y, Jiang D
Nat Commun (2022) 13 pp. 1286-1286 [ DOI: doi:10.1038/s41467-022-28808-5 Pubmed: 35277491 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- [(1s,2r,3r,4r,5r,6s,8r,9s,13s,16s,17r,18r)-11-ethyl-5-hydroxy-6,16,18-trimethoxy-4-(4-methoxybenzoyl)-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-8-yl] acetate (627 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel complex of type 3 subunit alpha with auxiliary subunits bata-1 and bata-2 (Complex from Homo sapiens)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Sodium channel protein type 3 subunit alpha (221 kDa, Protein from Homo sapiens)
Cryo-EM structure of human NaV1.3/beta1/beta2-ICA121431
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 7w7f
Q-score: 0.44
Li X, Xu F, Xu H, Zhang S, Gao Y, Zhang H, Dong Y, Zheng Y, Yang B, Sun J, Zhang XC, Zhao Y, Jiang D
Nat Commun (2022) 13 pp. 1286-1286 [ DOI: doi:10.1038/s41467-022-28808-5 Pubmed: 35277491 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Sodium channel complex of type 3 subunit alpha with auxiliary beta-1 and beta-2 (Complex from Homo sapiens)
- 2,2-diphenyl-~{n}-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]ethanamide (449 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 3 subunit alpha (226 kDa, Protein from Homo sapiens)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 6sj7
Q-score: 0.46
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J
Nat Chem Biol (2020) 16 pp. 15-23 [ Pubmed: 31819272 DOI: doi:10.1038/s41589-019-0411-6 ]
- Ddb1 complex (210 kDa, Complex)
- Det1- and ddb1-associated protein 1 (11 kDa, Protein from Homo sapiens)
- Rbm39 (Complex from Homo sapiens)
- Ddb1-dda1-dcaf15-rbm39 complex (Complex from Homo sapiens)
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
- Ddb1- and cul4-associated factor 15 (66 kDa, Protein from Homo sapiens)
- N~1~-(3-chloro-1h-indol-7-yl)benzene-1,4-disulfonamide (385 Da, Ligand)
- Rna binding protein 39 (9 kDa, Protein from Homo sapiens)