Computationally Designed, Expandable O4 Octahedral Handshake Nanocage
Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D
Nature (2024) 627 pp. 898-904 [ DOI: doi:10.1038/s41586-024-07188-4 Pubmed: 38480887 ]
Computational Designed Nanocage O43_129_+8
Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D
Nature (2024) 627 pp. 898-904 [ DOI: doi:10.1038/s41586-024-07188-4 Pubmed: 38480887 ]
- O43-129_+8 (2 MDa, Complex from unidentified)
- Cage_o43_129_a (Macromolecule from unidentified)
- Cage_o43_129_+8_b (Macromolecule from unidentified)
Twistless helix 12 repeat ring design R12B
Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D
Nature (2024) 627 pp. 898-904 [ DOI: doi:10.1038/s41586-024-07188-4 Pubmed: 38480887 ]
- R12b (Protein from synthetic construct)
- Twistless helix 12 repeat ring design r12b (155 kDa, Complex from synthetic construct)
Cryo-EM structure of synthetic tetrameric building block sC4
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8gel
Q-score: 0.439
Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D
Nature (2024) 627 pp. 898-904 [ DOI: doi:10.1038/s41586-024-07188-4 Pubmed: 38480887 ]
- Sc4 (57 kDa, Protein from synthetic construct)
- De novo designed tetramer sc4 (Complex from synthetic construct)
CryoEM Structure of a Computationally Designed T3 Tetrahedral Nanocage
Resolution: 4.05 Å
EM Method: Single-particle
Fitted PDBs: 8tl7
Q-score: 0.338
Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D
Nature (2024) 627 pp. 898-904 [ DOI: doi:10.1038/s41586-024-07188-4 Pubmed: 38480887 ]
- T3 tetrahedral cage (Complex from unidentified)
- Computationally designed protein (78 kDa, Protein from synthetic construct)
Computational Designed Nanocage O43_129
Resolution: 6.77 Å
EM Method: Single-particle
Fitted PDBs: 8v2d
Q-score: 0.201
Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D
Nature (2024) 627 pp. 898-904 [ DOI: doi:10.1038/s41586-024-07188-4 Pubmed: 38480887 ]
- O43_129 component a (33 kDa, Protein from synthetic construct)
- Nanocage o43_129 (1 MDa, Complex from unidentified)
- O43_129 component b (34 kDa, Protein from synthetic construct)
Computational Designed Nanocage O43_129_+4
Resolution: 6.4 Å
EM Method: Single-particle
Fitted PDBs: 8v3b
Q-score: 0.217
Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D
Nature (2024) 627 pp. 898-904 [ DOI: doi:10.1038/s41586-024-07188-4 Pubmed: 38480887 ]
- O43_129_+4 component b (46 kDa, Protein from synthetic construct)
- O43_129_+4 component a (33 kDa, Protein from synthetic construct)
- Computational designed nanocage o43_129_+4 (Complex from unidentified)
Cryo-EM map of synthetic cage_O3_10 reconstructed without symmetry (C1)
Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D
Nature (2024) 627 pp. 898-904 [ DOI: doi:10.1038/s41586-024-07188-4 Pubmed: 38480887 ]
Cryo-EM map of synthetic cage_O3_10 reconstructed with O symmetry
Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D
Nature (2024) 627 pp. 898-904 [ DOI: doi:10.1038/s41586-024-07188-4 Pubmed: 38480887 ]
Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Weidle C, Han HL, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D
bioRxiv (2023) [ DOI: doi:10.1101/2023.06.09.544258 Pubmed: 37333359 ]