Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 9chu
Q-score: 0.478
Xu J, Chen G, Wang H, Cao S, Heng J, Deupi X, Du Y, Kobilka BK
PNAS (2024) 121 pp. e2414544121-e2414544121 [ Pubmed: 39565314 DOI: doi:10.1073/pnas.2414544121 ]
- Beta-2 adrenergic receptor,calcineurin subunit b type 1 (49 kDa, Protein from Homo sapiens)
- 8-deethyl-8-[but-3-enyl]-ascomycin (804 Da, Ligand)
- Calcineurin fused beta2ar (Complex from Homo sapiens)
- Protein phosphatase 3 catalytic subunit alpha (Complex from Mus musculus)
- Calcineurin fused beta2ar in complex with fkbp12 (Complex)
- Protein phosphatase 3 catalytic subunit alpha (42 kDa, Protein from Mus musculus)
- Fkbp1a (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Homo sapiens)
- Noradrenaline (170 Da, Ligand)
cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in apo state
Resolution: 3.95 Å
EM Method: Single-particle
Fitted PDBs: 9chv
Q-score: 0.39
Xu J, Chen G, Wang H, Cao S, Heng J, Deupi X, Du Y, Kobilka BK
PNAS (2024) 121 pp. e2414544121-e2414544121 [ Pubmed: 39565314 DOI: doi:10.1073/pnas.2414544121 ]
- Calcineurin fused beta2ar in complex with fkbp12 (Complex)
- 8-deethyl-8-[but-3-enyl]-ascomycin (804 Da, Ligand)
- Protein phosphatase 3 catalytic subunit alpha (42 kDa, Protein from Mus musculus)
- Beta-2 adrenergic receptor,calcineurin subunit b type 1 (51 kDa, Protein from Homo sapiens)
- Fkbp1a (Complex from Homo sapiens)
- Calcineurin fused beta2ar (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Homo sapiens)
- Protein phosphatase 3 catalytic subunit alpha (Complex from Mus musculus)
cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in carazolol bound inactive state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9chx
Q-score: 0.431
Xu J, Chen G, Wang H, Cao S, Heng J, Deupi X, Du Y, Kobilka BK
PNAS (2024) 121 pp. e2414544121-e2414544121 [ Pubmed: 39565314 DOI: doi:10.1073/pnas.2414544121 ]
- (2s)-1-(9h-carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol (298 Da, Ligand)
- 8-deethyl-8-[but-3-enyl]-ascomycin (804 Da, Ligand)
- Calcineurin fused beta2ar (Complex from Homo sapiens)
- Beta-2 adrenergic receptor,calcineurin subunit b type 1 (51 kDa, Protein from Homo sapiens)
- Protein phosphatase 3 catalytic subunit alpha (Complex from Mus musculus)
- Calcineurin fused beta2ar in complex with fkbp12 (Complex)
- Protein phosphatase 3 catalytic subunit alpha (42 kDa, Protein from Mus musculus)
- Fkbp1a (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9arv
Q-score: 0.311
Xiang Y, Xu J, McGovern BL, Ranzenigo A, Huang W, Sang Z, Shen J, Diaz-Tapia R, Pham ND, Teunissen AJP, Rodriguez ML, Benjamin J, Taylor DJ, van Leent MMT, White KM, Garcia-Sastre A, Zhang P, Shi Y
Cell (2024) 187 pp. 6966-6980.e23 [ Pubmed: 39447570 DOI: doi:10.1016/j.cell.2024.09.043 ]
- Immunoglobulin j chain (19 kDa, Protein from Homo sapiens)
- Isoform 1 of immunoglobulin heavy constant mu (41 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Adaptive multi-epitope targeting and avidity-enhanced (ameta) nanobody platform (Complex from Homo sapiens)
a peptide receptor complex structure
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xgu
Q-score: 0.482
Wu Z, Chen G, Qiu C, Yan X, Xu L, Jiang S, Xu J, Han R, Shi T, Liu Y, Gao W, Wang Q, Li J, Ye F, Pan X, Zhang Z, Ning P, Zhang B, Chen J, Du Y
Sci Adv (2024) 10 pp. eadn7771-eadn7771 [ Pubmed: 39151001 DOI: doi:10.1126/sciadv.adn7771 ]
- Tak448 (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Kiss1r (Complex from Homo sapiens)
- Kp54-kiss1r-gq-scfv16 (130 kDa, Complex from Homo sapiens)
- Kiss-1 receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9flp
Q-score: 0.436
Lien YW, Amendola D, Lee KS, Bartlau N, Xu J, Furusawa G, Polz MF, Stocker R, Weiss GL, Pilhofer M
Science (2024) 386 pp. eadp0614-eadp0614 [ DOI: doi:10.1126/science.adp0614 Pubmed: 39418385 ]
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9fls
Q-score: 0.532
Lien YW, Amendola D, Lee KS, Bartlau N, Xu J, Furusawa G, Polz MF, Stocker R, Weiss GL, Pilhofer M
Science (2024) 386 pp. eadp0614-eadp0614 [ Pubmed: 39418385 DOI: doi:10.1126/science.adp0614 ]
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9flu
Q-score: 0.525
Lien YW, Amendola D, Lee KS, Bartlau N, Xu J, Furusawa G, Polz MF, Stocker R, Weiss GL, Pilhofer M
Science (2024) 386 pp. eadp0614-eadp0614 [ DOI: doi:10.1126/science.adp0614 Pubmed: 39418385 ]
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9flv
Q-score: 0.486
Lien YW, Amendola D, Lee KS, Bartlau N, Xu J, Furusawa G, Polz MF, Stocker R, Weiss GL, Pilhofer M
Science (2024) 386 pp. eadp0614-eadp0614 [ DOI: doi:10.1126/science.adp0614 Pubmed: 39418385 ]
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 9flw
Q-score: 0.472
Lien YW, Amendola D, Lee KS, Bartlau N, Xu J, Furusawa G, Polz MF, Stocker R, Weiss GL, Pilhofer M
Science (2024) 386 pp. eadp0614-eadp0614 [ Pubmed: 39418385 DOI: doi:10.1126/science.adp0614 ]