VMAT1 dimer with MPP+ and reserpine
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8tgg
Q-score: 0.371
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Reserpine (608 Da, Ligand)
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- 1-methyl-4-phenylpyridin-1-ium (170 Da, Ligand)
- Complex of vmat1 with mpp+ and reserpine (105 kDa, Complex from Homo sapiens)
VMAT1 dimer with amphetamine and reserpine
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tgh
Q-score: 0.479
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Complex of vmat1 with amphetamine and reserpine (105 kDa, Complex from Homo sapiens)
- Reserpine (608 Da, Ligand)
- (2s)-1-phenylpropan-2-amine (135 Da, Ligand)
VMAT1 dimer with dopamine and reserpine
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8tgi
Q-score: 0.396
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- L-dopamine (153 Da, Ligand)
- Reserpine (608 Da, Ligand)
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Complex of vmat1 dimer with dopamine and reserpine (105 kDa, Complex from Homo sapiens)
VMAT1 dimer in unbound form and with reserpine
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tgj
Q-score: 0.363
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Reserpine (608 Da, Ligand)
- Vmat1 dimer in unbound form and with reserpine (50 kDa, Protein from Homo sapiens)
- Complex of vmat1 dimer in unbound form and with reserpine (105 kDa, Complex from Homo sapiens)
VMAT1 dimer with histamine and reserpine
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8tgk
Q-score: 0.42
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Complex of vmat1 dimer with histamine and reserpine (105 kDa, Complex from Homo sapiens)
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Reserpine (608 Da, Ligand)
- Histamine (111 Da, Ligand)
VMAT1 dimer with norepinephrine and reserpine
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8tgl
Q-score: 0.413
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Reserpine (608 Da, Ligand)
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Complex of vmat1 with norepinephrine and reserpine (105 kDa, Complex from Homo sapiens)
- L-norepinephrine (169 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tgm
Q-score: 0.457
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Reserpine (608 Da, Ligand)
- Vmat1 dimer with reserpine (105 kDa, Complex from Homo sapiens)
- Vmat1 dimer with reserpine (50 kDa, Protein from Homo sapiens)
VMAT1 dimer with serotonin and reserpine
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8tgn
Q-score: 0.365
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Vmat1 dimer with serotonin and reserpine (105 kDa, Complex from Homo sapiens)
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Reserpine (608 Da, Ligand)
- Serotonin (176 Da, Ligand)
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 7wp8
Q-score: 0.441
Wu Y, Wang S, Zhang Y, Yuan L, Zheng Q, Wei M, Shi Y, Wang Z, Ma J, Wang K, Nie M, Xiao J, Huang Z, Chen P, Guo H, Lan M, Xu J, Hou W, Hong Y, Chen D, Sun H, Xiong H, Zhou M, Liu C, Guo W, Guo H, Gao J, Gan C, Li Z, Zhang H, Wang X, Li S, Cheng T, Zhao Q, Chen Y, Wu T, Zhang T, Zhang J, Cao H, Zhu H, Yuan Q, Guan Y, Xia N
Cell Host Microbe (2022) 30 pp. 1732-1744.e7 [ Pubmed: 36323313 DOI: doi:10.1016/j.chom.2022.10.011 ]
- 83h7 light chain (11 kDa, Protein from Mus musculus)
- 85f7 heavy chain (13 kDa, Protein from Mus musculus)
- Spike protein stfk1628x (Complex)
- 83h7 heavy chain (13 kDa, Protein from Mus musculus)
- 2b4 light chain (12 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (20 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 85f7 light chain (11 kDa, Protein from Mus musculus)
- Cryo-em structure of sars-cov-2 recombinant spike protein stfk1628x in complex with three neutralizing antibodies (Complex from Mus musculus)
- 2b4 heavy chain (13 kDa, Protein from Mus musculus)
- Neutralizing antibodies (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 7wp6
Q-score: 0.438
Wu Y, Wang S, Zhang Y, Yuan L, Zheng Q, Wei M, Shi Y, Wang Z, Ma J, Wang K, Nie M, Xiao J, Huang Z, Chen P, Guo H, Lan M, Xu J, Hou W, Hong Y, Chen D, Sun H, Xiong H, Zhou M, Liu C, Guo W, Guo H, Gao J, Gan C, Li Z, Zhang H, Wang X, Li S, Cheng T, Zhao Q, Chen Y, Wu T, Zhang T, Zhang J, Cao H, Zhu H, Yuan Q, Guan Y, Xia N
Cell Host Microbe (2022) 30 pp. 1732-1744.e7 [ Pubmed: 36323313 DOI: doi:10.1016/j.chom.2022.10.011 ]
- 83h7 light chain (11 kDa, Protein from Mus musculus)
- 36h6 light chain (12 kDa, Protein from Mus musculus)
- Cryo-em structure of sars-cov-2 recombinant spike protein stfk in complex with three neutralizing antibodies (Complex from Mus musculus)
- 83h7 heavy chain (13 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 36h6 heavy chain (13 kDa, Protein from Mus musculus)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 85f7 light chain (11 kDa, Protein from Mus musculus)
- 85f7 heavy chain (13 kDa, Protein from Mus musculus)
- Neutralizing antibodies (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein stfk (Complex)