Cryo-EM structure of human alpha-fetoprotein
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8x1n
Q-score: 0.518
Liu K, Wu C, Zhu M, Xu J, Lin B, Lin H, Liu Z, Li M
Commun Biol (2024) 7 pp. 505-505 [ Pubmed: 38678117 DOI: doi:10.1038/s42003-024-06219-0 ]
- Palmitic acid (256 Da, Ligand)
- Cryo-em structure of human alpha-fetoprotein (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Alpha-fetoprotein (68 kDa, Protein from Homo sapiens)
Cryo-EM structure of streptavidin
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8hrm
Q-score: 0.518
Zheng L, Xu J, Wang W, Gao X, Zhao C, Guo W, Sun L, Cheng H, Meng F, Chen B, Sun W, Jia X, Zhou X, Wu K, Liu Z, Ding F, Liu N, Wang HW, Peng H
Nat Commun (2024) 15 pp. 7300-7300 [ DOI: doi:10.1038/s41467-024-51696-w Pubmed: 39181869 ]
- Streptavidin (12 kDa, Protein from Streptomyces avidinii)
- Water (18 Da, Ligand)
- Streptavidin (Complex from Streptomyces avidinii)
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ej8
Q-score: 0.482
Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y
Sci Adv (2022) 8 pp. eabj5347-eabj5347 [ DOI: doi:10.1126/sciadv.abj5347 Pubmed: 35245122 ]
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 (32 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Alpha2a-adrenergic receptor go signaling complex (Complex from Homo sapiens)
- Alpha-2a adrenergic receptor (50 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Alpha2a-adrenergic receptor go signaling complex (Complex)
- Brimonidine (292 Da, Ligand)
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to dexmedetomidine
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7eja
Q-score: 0.378
Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y
Sci Adv (2022) 8 pp. eabj5347-eabj5347 [ DOI: doi:10.1126/sciadv.abj5347 Pubmed: 35245122 ]
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 (32 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Alpha2a-adrenergic receptor go signaling complex (Complex from Homo sapiens)
- Alpha-2a adrenergic receptor (50 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- 4-[(1~{s})-1-(2,3-dimethylphenyl)ethyl]-1~{h}-imidazole (200 Da, Ligand)
- Alpha2a-adrenergic receptor go signaling complex (Complex)
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to oxymetazoline
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7ejk
Q-score: 0.453
Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y
Sci Adv (2022) 8 pp. eabj5347-eabj5347 [ DOI: doi:10.1126/sciadv.abj5347 Pubmed: 35245122 ]
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 (32 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Alpha2a-adrenergic receptor go signaling complex (Complex from Homo sapiens)
- Alpha-2a adrenergic receptor (50 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Oxymetazoline (260 Da, Ligand)
- Alpha2a-adrenergic receptor go signaling complex (Complex)
Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7ejx
Q-score: 0.606
Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y
Nat Commun (2022) 13 pp. 2375-2375 [ Pubmed: 35501348 DOI: doi:10.1038/s41467-022-30081-5 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpr88-gi1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (1r,2r)-n-[(2s,3s)-2-azanyl-3-methyl-pentyl]-n-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide (455 Da, Ligand)
- Scfv16 (Complex from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Probable g-protein coupled receptor 88 (40 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Gpr88-gi1 signaling complex (Complex)
cryo-EM structure of alpha2BAR-GoA complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6k41
Q-score: 0.556
Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK
Nat Chem Biol (2020) 16 pp. 507-512 [ DOI: doi:10.1038/s41589-020-0492-2 Pubmed: 32152538 ]
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Mus musculus)
- Scfv (32 kDa, Protein from Mus musculus)
- 4-[(1~{s})-1-(2,3-dimethylphenyl)ethyl]-1~{h}-imidazole (200 Da, Ligand)
- Alpha2bar-goa complex (150 kDa, Complex from Spodoptera)
- Alpha-2a adrenergic receptor,endolysin,alpha-2b adrenergic receptor,alpha-2b adrenergic receptor (58 kDa, Protein from Homo sapiens)
cryo-EM structure of alpha2BAR-Gi1 complex
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6k42
Q-score: 0.299
Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK
Nat Chem Biol (2020) 16 pp. 507-512 [ DOI: doi:10.1038/s41589-020-0492-2 Pubmed: 32152538 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv (32 kDa, Protein from Mus musculus)
- 4-[(1~{s})-1-(2,3-dimethylphenyl)ethyl]-1~{h}-imidazole (200 Da, Ligand)
- Alpha2bar-gi1 complex (150 kDa, Complex from Spodoptera)
- Alpha-2a adrenergic receptor,endolysin,alpha-2b adrenergic receptor,alpha-2b adrenergic receptor (58 kDa, Protein from Homo sapiens)