Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode I)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jcu
Q-score: 0.401
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ DOI: doi:10.1038/s41422-023-00830-2 Pubmed: 37286794 ]
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mglu2-3 heterodimer in presence of ly341495 (Complex from Homo sapiens)
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode II)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8jcv
Q-score: 0.344
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ DOI: doi:10.1038/s41422-023-00830-2 Pubmed: 37286794 ]
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Mglu2-3 heterodimer in presence of ly341495 (Complex from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jcw
Q-score: 0.434
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ DOI: doi:10.1038/s41422-023-00830-2 Pubmed: 37286794 ]
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Mglu2-3 heterodimer in presence of ly341495 and nam563 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jcx
Q-score: 0.421
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ DOI: doi:10.1038/s41422-023-00830-2 Pubmed: 37286794 ]
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Mglu2-3 heterodimer in presence of ly341495 and nam563 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jcy
Q-score: 0.443
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ DOI: doi:10.1038/s41422-023-00830-2 Pubmed: 37286794 ]
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
- Mglu2-3 heterodimer in presence of ly341495, nam563, and ly2389575 (Complex from Homo sapiens)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jcz
Q-score: 0.401
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ DOI: doi:10.1038/s41422-023-00830-2 Pubmed: 37286794 ]
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
- Mglu2-3 heterodimer in presence of ly341495, nam563, and ly2389575 (Complex from Homo sapiens)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of NAM563
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jd0
Q-score: 0.41
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ DOI: doi:10.1038/s41422-023-00830-2 Pubmed: 37286794 ]
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Mglu2-3 heterodimer in presence of nam563 (Complex from Homo sapiens)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 4-(1-methylpyrazol-4-yl)-7-[[(2~{s})-2-(trifluoromethyl)morpholin-4-yl]methyl]quinoline-2-carboxamide (419 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
Cryo-EM structure of mGlu2-mGlu3 heterodimer in Rco state
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8jd1
Q-score: 0.369
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ DOI: doi:10.1038/s41422-023-00830-2 Pubmed: 37286794 ]
- Mglu2-mglu3 heterodimer in presence of glutamate, jnj-40411813, and cacl2 (Complex from Homo sapiens)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
Cryo-EM structure of G protein-free mGlu2-mGlu3 heterodimer in Acc state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jd2
Q-score: 0.479
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ DOI: doi:10.1038/s41422-023-00830-2 Pubmed: 37286794 ]
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Mglu2-3 heterodimer in presence of glutamate, jnj-40411813, and cacl2 (Complex from Homo sapiens)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
Cryo-EM structure of Gi1-bound mGlu2-mGlu3 heterodimer
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jd3
Q-score: 0.409
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ DOI: doi:10.1038/s41422-023-00830-2 Pubmed: 37286794 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Di-palmitoyl-3-sn-phosphatidylethanolamine (691 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Metabotropic glutamate receptor 2 (95 kDa, Protein from Homo sapiens)
- 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one (344 Da, Ligand)
- Gi1-bound mglu2-mglu3 heterodimer (Complex from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 3 (100 kDa, Protein from Homo sapiens)